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Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults

Citation

Dore, D and Martens, A and Quinn, S and Ding, C and Winzenberg, T and Zhai, G and Pelletier, JP and Martel-Pelletier, J and Abram, F and Cicuttini, F and Jones, G, Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults, Arthritis Research & Therapy, 12, (6) EJ ISSN 1478-6354 (2010) [Refereed Article]


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Copyright Statement

© 2010 Dore et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The electronic version of this article is the complete one and can be found online at: http://arthritis-research.com/content/12/6/R222

Official URL: http://arthritis-research.com/content/12/6/R222

DOI: doi:10.1186/ar3209

Abstract

Introduction: Recent evidence suggests that bone marrow lesions (BMLs) play a pivotal role in knee osteoarthritis (OA). The aims of this study were to determine: 1) whether baseline BML presence and/or severity predict sitespecific cartilage defect progression and cartilage volume loss; and 2) whether baseline cartilage defects predict site-specific BML progression. Methods: A total of 405 subjects (mean age 63 years, range 52 to 79) were measured at baseline and approximately 2.7 years later. Magnetic resonance imaging (MRI) of the right knee was performed to measure knee cartilage volume, cartilage defects (0 to 4), and BMLs (0 to 3) at the medial tibial (MT), medial femoral (MF), lateral tibial (LT), and lateral femoral (LF) sites. Logistic regression and generalized estimating equations were used to examine the relationship between BMLs and cartilage defects and cartilage volume loss. Results: At all four sites, baseline BML presence predicted defect progression (odds ratio (OR) 2.4 to 6.4, all P < 0.05), and cartilage volume loss (-0.9 to -2.9% difference per annum, all P < 0.05) at the same site. In multivariable analysis, there was a significant relationship between BML severity and defect progression at all four sites (OR 1.8 to 3.2, all P < 0.05) and BML severity and cartilage volume loss at the MF, LT, and LF sites (b -22.1 to -42.0, all P < 0.05). Additionally, baseline defect severity predicted BML progression at the MT and LF sites (OR 3.3 to 3.7, all P < 0.01). Lastly, there was a greater increase in cartilage volume loss at the MT and LT sites when both larger defects and BMLs were present at baseline (all P < 0.05). Conclusions: Baseline BMLs predicted site-specific defect progression and cartilage volume loss in a dose-response manner suggesting BMLs may have a local effect on cartilage homeostasis. Baseline defects predicted site-specific BML progression, which may represent increased bone loading adjacent to defects. These results suggest BMLs and defects are interconnected and play key roles in knee cartilage volume loss; thus, both should be considered targets for intervention.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
UTAS Author:Dore, D (Associate Professor Dawn Aitken)
UTAS Author:Martens, A (Miss Ashleigh Martens)
UTAS Author:Quinn, S (Dr Stephen Quinn)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
UTAS Author:Winzenberg, T (Professor Tania Winzenberg)
UTAS Author:Jones, G (Professor Graeme Jones)
ID Code:66748
Year Published:2010
Web of Science® Times Cited:55
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-02-10
Last Modified:2011-05-03
Downloads:362 View Download Statistics

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