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Assessment of airway inflammation using sputum, BAL, and endobronchial biopsies in current and ex-smokers with established COPD

Citation

Wen, Y and Reid, DW and Zhang, D and Ward, C and Wood-Baker, R and Walters, EH, Assessment of airway inflammation using sputum, BAL, and endobronchial biopsies in current and ex-smokers with established COPD, International Journal of Chronic Obstructive Pulmonary Disease, 5 pp. 327-334. ISSN 1178-2005 (2010) [Refereed Article]


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Official URL: http://www.dovepress.com/assessment-of-airway-infl...

DOI: doi:10.2147/COPD.S11343

Abstract

Rationale: Smoking effects on physiological and gross pathology in chronic obstructive pulmonary disease (COPD) are relatively well described. However, there is little known in COPD about the detailed interrelationships between lung function and inflammatory profiles in different airway compartments from the same individual and whether airway inflammation in these different compartments differs in ex- and current smokers with established COPD. Objectives: We compared sputum, bronchoalveolar (BAL), and airway wall inflammatory profiles in current versus ex-smokers and related this to smoking intensity and lung function in 17 current and 17 ex-smokers with mild to moderate COPD. Results: Current smokers had more sputum mast cells (% differential and absolute numbers), whereas ex-smokers had increased sputum neutrophils. In BAL, there was a significant increase in eosinophils in current smokers, but ex-smokers had significantly increased neutrophils, lymphocytes, and epithelial cells. There were no cell profile differences observed in airway biopsies between current and ex-smokers and there were no correlations between the individual inflammatory cell populations in any of the airway compartments. In current smokers only, smoking intensity was negatively correlated with lung function, and associated with a reduction in overall cellularity of both sputum and BAL. Conclusion: Airway inflammation persists in ex-smokers with COPD, but differs from COPD current smokers. The impact of smoking appears to vary in different airway compartments and any direct relationships between cellularity and lung function tended to be negative, ie, worse lung function indicated the presence of fewer cells.

Item Details

Item Type:Refereed Article
Keywords:current smokers, ex-smokers, airway cellularity, sputum, BAL, endobronchial biopsies
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
UTAS Author:Wen, Y (Dr Yudong Wen)
UTAS Author:Reid, DW (Dr David Reid)
UTAS Author:Zhang, D (Mr Dong Zhang)
UTAS Author:Ward, C (Dr Christopher Ward)
UTAS Author:Wood-Baker, R (Professor Richard Wood-Baker)
UTAS Author:Walters, EH (Professor Haydn Walters)
ID Code:66614
Year Published:2010
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-02-03
Last Modified:2012-09-05
Downloads:545 View Download Statistics

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