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Poor lung function and tonsillectomy in childhood are associated with mortality from age 18 to 44


Meszaros, D and Dharmage, SC and Matheson, MC and Venn, A and Wharton, CL and Johns, DP and Abramson, MJ and Giles, GG and Hopper, JL and Walters, EH, Poor lung function and tonsillectomy in childhood are associated with mortality from age 18 to 44, Respiratory Medicine, 104, (6) pp. 808-815. ISSN 0954-6111 (2010) [Refereed Article]

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DOI: doi:10.1016/j.rmed.2009.12.001


Background: The aim of this analysis was to examine associations between lung health in childhood and mortality between ages 18 and 44 years in the Tasmanian Longitudinal Health Study (TAHS). Methods: The 1961 Tasmanian birth cohort who attended school in 1968 (nZ8583) were linked to the Australian National Death Index (NDI) to identify deaths. Additional deaths were notified by families through a 37 year follow-up postal questionnaire. Information on lung health at age 7 years and on potential confounders was obtained from the original 1968 TAHS survey and school medical records. Cox proportional hazards modelling was used to assess determinants of mortality. Results: A total of 264 (3%) deaths were identified. The principal causes of death were external injury (56.1%, nZ97) and cancer (17.9%, nZ31). Males were more likely than females to have died (pZ<0.1). Only two (1.1%) participants had died from respiratory conditions. Having an FEV1 < 80% predicted at 7 years of age was associated with a 2-fold increased incidence of death. Tonsillectomy before age 7 years was associated with a 1.5-fold increase in mortality (pZ0.05); being male with a 3.6-fold increase in mortality (pZ0.0001); and repeated chest illnesses at age 7 years causing >30 days confinement in the last year, was associated with a 2.2-fold increase in mortality (pZ0.03). Conclusions: Childhood lung health appears to be associated with increased mortality in adulthood, perhaps by affectingthe ability to survivetrauma,major illnesses and other physical stresses.

Item Details

Item Type:Refereed Article
Keywords:Birth cohort; Childhood lung health; Chronic respiratory disease; Epidemiology; Mortality; Risk factors
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Immunogenetics (incl. genetic immunology)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Meszaros, D (Dr Desiree Meszaros)
UTAS Author:Venn, A (Professor Alison Venn)
UTAS Author:Johns, DP (Associate Professor David Johns)
UTAS Author:Walters, EH (Professor Haydn Walters)
ID Code:66610
Year Published:2010
Web of Science® Times Cited:4
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-02-03
Last Modified:2014-11-24

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