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The role of latitude, ultraviolet radiation exposure and vitamin D in childhood asthma and hayfever: an Australian multicenter study

Citation

Hughes, AM and Lucas, RM and Ponsonby, AL and Chapman, C and Coulthard, A and Dear, K and Dwyer, T and Kilpatrick, TJ and McMichael, AJ and Pender, MP and Taylor, BV and Valery, P and van der Mei, IAF and Williams, D, The role of latitude, ultraviolet radiation exposure and vitamin D in childhood asthma and hayfever: an Australian multicenter study , Pediatric Allergy and Immunology, 22, (Epub ahead of print 30 September 2010) pp. 327-333. ISSN 0905-6157 (2010) [Refereed Article]


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The definitive published version is available online at: http://onlinelibrary.wiley.com/

DOI: doi:10.1111/j.1399-3038.2010.01099.x

Abstract

Observations of increasing allergy prevalence with decreasing distance from the Equator and positive associations with ambient ultraviolet radiation have contributed to a growing interest in the possible role of vitamin D in the etiology of allergy. The aims of this study were to describe any latitudinal variation in the prevalence of childhood allergy in Australia and to evaluate, in parallel, the individual associations between ultraviolet radiation (UVR)- and vitamin D-related measures and hayfever asthma and both conditions. Participants were population- based controls who took part in a multicenter case–control study, aged 18–61 yr and resident in one of four study regions ranging in latitude from 27S to 43S. Data were derived from a self-administered questionnaire, interview and examination by a research officer and biologic sampling. Latitude and longitude coordinates were geocoded from participants residential locations and climatic data were linked to postcodes of current residence. Stored serum was analyzed for 25- hydroxyvitamin D concentrations and silicone rubber casts of the skin were used as an objective measure of cumulative actinic damage. There was an inverse latitude gradient for asthma (a 9% decrease per increasing degree of latitude); however, this pattern did not persist after adjusting for average daily temperature. There was no association between any of the UVR- or vitamin D-related measures and childhood asthma, but greater time in the sun in winter between the ages 6–15 yr was associated with an increase in the odds of having hayfever [adjusted odds ratios (OR) 1.29; 95% CI 1.01–1.63]. Oral supplementation with cod liver oil in childhood increased the odds of a history of having both asthma and hayfever (2.87; 1.00–8.32). Further investigation of the possible role of early vitamin D supplementation in the development of allergy is warranted. Our results also suggest that solar exposure during childhood may be important in allergic sensitization. Plausible explanations, including biologic mechanisms, exist for both observations.

Item Details

Item Type:Refereed Article
Keywords:epidemiology; allergy; asthma; hayfever; allergic rhinitis; Australia; latitude; ultraviolet radiation; vitamin D; food allergy; eczema
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Preventive Medicine
Author:Taylor, BV (Professor Bruce Taylor)
Author:van der Mei, IAF (Associate Professor Ingrid van der Mei)
ID Code:66542
Year Published:2010
Web of Science® Times Cited:56
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-02-02
Last Modified:2011-05-03
Downloads:0

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