The effect of a high-fat meal on postprandial arterial stiffness in men with obesity and Type 2 diabetes
Phillips, LK and Peake, JM and Zhang, X and Hickman, IJ and Kolade, O and Sacre, JW and Huang, BE and Simpson, P and Li, SH and Whitehead, JP and Sharman, JE and Martin, JH and Prins, JB, The effect of a high-fat meal on postprandial arterial stiffness in men with obesity and Type 2 diabetes, Journal of Clinical Endocrinology and Metabolism, 95, (9) pp. 4455-4459. ISSN 0021-972X (2010) [Refereed Article]
Context: Postprandial dysmetabolism is emerging as an important cardiovascular risk factor. Augmentation
index (AIx) is a measure of systemic arterial stiffness and independently predicts cardiovascular
Objective: The objective of this study was to assess the effect of a standardized high-fat meal on
metabolic parameters and AIx in 1) lean, 2) obese nondiabetic, and 3) subjects with type 2 diabetes
Design and Setting: Male subjects (lean, n 8; obese, n 10; and T2DM, n 10) were studied
for 6 h after a high-fat meal and water control. Glucose, insulin, triglycerides, and AIx (radial
applanation tonometry) were measured serially to determine the incremental area under the
Results: AIx decreased in all three groups after a high-fat meal. A greater overall postprandial reduction
in AIx was seen in lean andT2DMcompared with obese subjects (iAUC, 22511204, 27641102,
and 1187 429% min, respectively; P 0.05). The time to return to baseline AIx was significantly
delayed in subjects with T2DM (297 68 min) compared with lean subjects (161 88 min; P 0.05).
There was a significant correlation between iAUC AIx and iAUC triglycerides (r 0.50; P 0.05).
Conclusions: Obesity is associated with an attenuated overall postprandial decrease in AIx. Subjects
with T2DM have a preserved, but significantly prolonged, reduction in AIx after a high-fat meal.
The correlation between AIx and triglycerides suggests that postprandial dysmetabolism may
impact on vascular dynamics. The markedly different response observed in the obese subjects
compared with those with T2DM was unexpected and warrants additional evaluation.