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Effect of increased preload on the synthesized aortic blood pressure waveform

Citation

Heffernan, KS and Sharman, JE and Yoon, ES and Kim, EJ and Jung, SJ and Jae, SY, Effect of increased preload on the synthesized aortic blood pressure waveform, Journal of Applied Physiology, 109, (2) pp. 484-490. ISSN 8750-7587 (2010) [Refereed Article]


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Copyright Statement

Copyright © 2010 the American Physiological Society

Official URL: http://jap.physiology.org/content/109/2/484

DOI: doi:10.1152/japplphysiol.00196.2010

Abstract

Effect of increased preload on the synthesized aortic blood pressure waveform. J Appl Physiol 109: 484–490, 2010. First published June 17, 2010; doi:10.1152/japplphysiol.00196.2010.—In the present study, we examined the influence of preload augmentation via passive leg elevation (PLE) on synthesized aortic blood pressure, aortic augmentation index (AIx), and aortic capacitance (a reflection of aortic reservoir function). Central and peripheral hemodynamics were measured via tonometry with a generalized transfer function in 14 young, healthy men (age  24 yr). Aortic blood flow was calculated from the left ventricular outflow tract (LVOT) velocity-time integral (VTI) using standard two-dimensional echocardiographic-Doppler techniques. Measures were made in the supine position at rest (Pre), during PLE, and during recovery (Post). There was a significant increase in LVOT-VTI, synthesized aortic systolic blood pressure (BP) and AIx from Pre to PLE, with values returning to baseline Post (P  0.05). There was a reduction in aortic capacitance from Pre to PLE, with values returning to baseline Post (P  0.05). There was no change in heart rate, systemic arterial compliance, aortic elastance, aortic wave travel timing, or vascular resistance (P  0.05). Change in AIx from Pre to PLE was associated with change in LVOT-VTI (r  0.66, P  0.05) and inversely associated with change in aortic capacitance (r  0.73, P  0.05). These data suggest that in a setting of isolated augmented preload with minimal changes in other potential confounders, the morphology of the synthesized aortic BP waveform and AIx may be related to changes in aortic reservoir function.

Item Details

Item Type:Refereed Article
Keywords:augmentation index; blood pressure; aortic reservoir function; arterial compliance
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Sharman, JE (Professor James Sharman)
ID Code:66315
Year Published:2010
Web of Science® Times Cited:13
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-01-12
Last Modified:2011-05-02
Downloads:0

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