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Effect of increased preload on the synthesized aortic blood pressure waveform
Citation
Heffernan, KS and Sharman, JE and Yoon, ES and Kim, EJ and Jung, SJ and Jae, SY, Effect of increased preload on the synthesized aortic blood pressure waveform, Journal of Applied Physiology, 109, (2) pp. 484-490. ISSN 8750-7587 (2010) [Refereed Article]
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Copyright Statement
Copyright © 2010 the American Physiological Society
Official URL: http://jap.physiology.org/content/109/2/484
DOI: doi:10.1152/japplphysiol.00196.2010
Abstract
Effect of increased preload on the synthesized aortic blood
pressure waveform. J Appl Physiol 109: 484–490, 2010. First published
June 17, 2010; doi:10.1152/japplphysiol.00196.2010.—In the
present study, we examined the influence of preload augmentation via
passive leg elevation (PLE) on synthesized aortic blood pressure,
aortic augmentation index (AIx), and aortic capacitance (a reflection
of aortic reservoir function). Central and peripheral hemodynamics
were measured via tonometry with a generalized transfer function in
14 young, healthy men (age 24 yr). Aortic blood flow was calculated
from the left ventricular outflow tract (LVOT) velocity-time integral
(VTI) using standard two-dimensional echocardiographic-Doppler techniques.
Measures were made in the supine position at rest (Pre),
during PLE, and during recovery (Post). There was a significant
increase in LVOT-VTI, synthesized aortic systolic blood pressure
(BP) and AIx from Pre to PLE, with values returning to baseline Post
(P 0.05). There was a reduction in aortic capacitance from Pre to
PLE, with values returning to baseline Post (P 0.05). There was no
change in heart rate, systemic arterial compliance, aortic elastance,
aortic wave travel timing, or vascular resistance (P 0.05). Change
in AIx from Pre to PLE was associated with change in LVOT-VTI (r
0.66, P 0.05) and inversely associated with change in aortic
capacitance (r 0.73, P 0.05). These data suggest that in a
setting of isolated augmented preload with minimal changes in other
potential confounders, the morphology of the synthesized aortic BP
waveform and AIx may be related to changes in aortic reservoir
function.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | augmentation index; blood pressure; aortic reservoir function; arterial compliance |
| Research Division: | Medical and Health Sciences |
| Research Group: | Cardiorespiratory Medicine and Haematology |
| Research Field: | Cardiology (incl. Cardiovascular Diseases) |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Cardiovascular System and Diseases |
| Author: | Sharman, JE (Professor James Sharman) |
| ID Code: | 66315 |
| Year Published: | 2010 |
| Web of Science® Times Cited: | 13 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2011-01-12 |
| Last Modified: | 2011-05-02 |
| Downloads: | 0 |
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