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Influence of high-dose estrogen exposure during adolescence on mammographic density for age in adulthood


Jordan, HL and Hopper, JL and Thomson, RJ and Kavanagh, AM and Gertig, DM and Stone, J and Venn, AJ, Influence of high-dose estrogen exposure during adolescence on mammographic density for age in adulthood, Cancer Epidemiology, Biomarkers and Prevention, 19, (1) pp. 121-129. ISSN 1055-9965 (2010) [Refereed Article]

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Copyright 2010 American Association for Cancer Research

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DOI: doi:10.1158/1055-9965.EPI-09-0434


High-dose estrogen exposure during adolescence has been hypothesized to increase a woman's breast cancer risk, possibly mediated through an increase in mammographic density, a well-established breast cancer risk factor. In 2006 to 2007, we conducted a retrospective study of women assessed for tall stature as an adolescent between 1959 and 1993. Eligible participants were ages ≡40 years and treated during adolescence with 3 mg diethylstilbestrol or 150 米g ethinyl estradiol daily or untreated. Mammograms from 167 treated and 142 untreated women were digitized. Total breast area, dense area, nondense area, and percent density were measured using a computer thresholding technique. Data on potential determinants were collected from medical records and telephone interview. Treated women had, on average, 17% lower dense area (P = 0.032). Means (95% confidence intervals) adjusted for age and body mass index for treated and untreated women were 24.5 cm2 (21.8-27.2) and 29.1 cm2 (26.0-32.4), respectively. There was no difference in adjusted means (95% confidence intervals) between treated and untreated women for nondense area [71.7 cm2 (66.2-77.7) versus 70.5 cm2 (64.7-76.9); P = 0.78], percent dense area [24.8% (22.4-27.4) versus 27.7% (24.8-30.7); P = 0.16], or total area [105.6 cm2 (100.1-111.4) versus 109.3 cm2 (103.1-115.8); P = 0.41], respectively. High-dose estrogen exposure during adolescence appears to curtail growth of mammographically dense tissue and therefore is unlikely to increase breast cancer risk through mechanisms related to mammographic density.

Item Details

Item Type:Refereed Article
Keywords:mammographic density ,adolescence, hormones ,breast cancer, epidemiology
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Oncology and carcinogenesis not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Jordan, HL (Ms Helen Jordan)
UTAS Author:Thomson, RJ (Dr Russell Thomson)
UTAS Author:Venn, AJ (Professor Alison Venn)
ID Code:66301
Year Published:2010
Web of Science® Times Cited:6
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-01-12
Last Modified:2011-05-02

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