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Host resistance to malaria: using mouse models to explore the host response


Longley, R and Smith, C and Fortin, A and Berghout, J and McMorran, B and Burgio, G and Foote, S and Gros, P, Host resistance to malaria: using mouse models to explore the host response, Mammalian Genome, 22, (1-2) pp. 32-42. ISSN 0938-8990 (2011) [Refereed Article]

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DOI: doi:10.1007/s00335-010-9302-6


Malaria is a disease that infects over 500 million people, causing at least 1 million deaths every year, with the majority occurring in developing countries. The current antimalarial arsenal is becoming dulled due to the rapid rate of resistance of the parasite. However, in populations living in malaria-endemic regions there are many examples of genetic-based resistance to the severe effects of the parasite Plasmodium. Defining the genetic factors behind host resistance has been an area of great scientific interest over the last few decades; this review summarizes the current knowledge of the genetic loci involved. Perhaps the lessons learned from the natural variation in both the human populations and experimental mouse models of infection may pave the way for novel resistance-proof antimalarials.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Infectious diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Longley, R (Ms Rhea Longley)
UTAS Author:Smith, C (Dr Clare Smith)
UTAS Author:McMorran, B (Associate Professor Brendan McMorran)
UTAS Author:Burgio, G (Dr Gaetan Burgio)
UTAS Author:Foote, S (Professor Simon Foote)
ID Code:66105
Year Published:2011
Web of Science® Times Cited:37
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-12-22
Last Modified:2017-05-25

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