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Host resistance to malaria: using mouse models to explore the host response

Citation

Longley, R and Smith, C and Fortin, A and Berghout, J and McMorran, B and Burgio, G and Foote, S and Gros, P, Host resistance to malaria: using mouse models to explore the host response, Mammalian Genome, 22, (1-2) pp. 32-42. ISSN 0938-8990 (2010) [Refereed Article]


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The original publication is available at http://www.springerlink.com

Official URL: http://www.springerlink.com

DOI: doi:10.1007/s00335-010-9302-6

Abstract

Malaria is a disease that infects over 500 million people, causing at least 1 million deaths every year, with the majority occurring in developing countries. The current antimalarial arsenal is becoming dulled due to the rapid rate of resistance of the parasite. However, in populations living in malaria-endemic regions there are many examples of genetic-based resistance to the severe effects of the parasite Plasmodium. Defining the genetic factors behind host resistance has been an area of great scientific interest over the last few decades; this review summarizes the current knowledge of the genetic loci involved. Perhaps the lessons learned from the natural variation in both the human populations and experimental mouse models of infection may pave the way for novel resistance-proof antimalarials.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Infectious Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Longley, R (Ms Rhea Longley)
Author:Smith, C (Dr Clare Smith)
Author:McMorran, B (Dr Brendan McMorran)
Author:Burgio, G (Dr Gaetan Burgio)
Author:Foote, S (Professor Simon Foote)
ID Code:66105
Year Published:2010
Web of Science® Times Cited:16
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-12-22
Last Modified:2013-10-21
Downloads:0

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