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Host resistance to malaria: using mouse models to explore the host response
journal contribution
posted on 2023-05-17, 04:06 authored by Longley, R, Smith, C, Fortin, A, Berghout, J, McMorran, B, Burgio, G, Simon James FooteSimon James Foote, Gros, PMalaria is a disease that infects over 500 million people, causing at least 1 million deaths every year, with the majority occurring in developing countries. The current antimalarial arsenal is becoming dulled due to the rapid rate of resistance of the parasite. However, in populations living in malaria-endemic regions there are many examples of genetic-based resistance to the severe effects of the parasite Plasmodium. Defining the genetic factors behind host resistance has been an area of great scientific interest over the last few decades; this review summarizes the current knowledge of the genetic loci involved. Perhaps the lessons learned from the natural variation in both the human populations and experimental mouse models of infection may pave the way for novel resistance-proof antimalarials.
History
Publication title
Mammalian GenomeVolume
22Issue
1-2Pagination
32-42ISSN
0938-8990Department/School
Menzies Institute for Medical ResearchPublisher
Springer-VerlagPlace of publication
175 Fifth Ave, New York, USA, Ny, 10010Rights statement
The original publication is available at http://www.springerlink.comRepository Status
- Restricted