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Identification of early knee osteoarthritis - a new horizon

Citation

Teichtahl, AJ and Wluka, AE and Wang, Y and Jones, G and Ding, C and Cicuttini, FM, Identification of early knee osteoarthritis - a new horizon, Current Rheumatology Reviews , 6, (4) pp. 251-256. ISSN 1573-3971 (2010) [Refereed Article]


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Copyright Statement

Copyright 2010 Bentham Science Publishers

Official URL: http://www.bentham.org/

DOI: doi:10.2174/157339710793205648

Abstract

Knee osteoarthritis (OA) is a common and significant cause of disability. Until recently, the major investigation to help establish a diagnosis of knee OA was the joint radiograph. This imaging modality offers only a two-dimensional image of a three-dimensional structure, and can only crudely identify major joint abnormalities at the later stage of disease. Moreover, joint radiographs cannot fully characterise subtle changes in intra and extraarticular structures, such as cartilage and bone marrow abnormalities that are now considered to be part of a whole-organ disease process. The recent advent of Magnetic Resonance Imaging (MRI) has enabled a three-dimensional assessment of the entire joint, thus providing new insights into the natural history of joint arthropathies. It is likely that morphological changes in articular structures caused by the OA process have their origins in the apparently healthy asymptomatic knee joint. MRI has therefore enabled the opportunity to better examine and understand pre-clinical and very subtle early aberrations in joint morphology, prior to the onset of radiographic disease. This discussion seeks to explore knee OA as a disease entity that can be recognised before any radiographic change. This may pose new, yet exciting challenges for the identification and classification of disease, and provide a better understand of the pathogenesis of knee OA.

Item Details

Item Type:Refereed Article
Keywords:Knee, osteoarthritis, cartilage, bone
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Jones, G (Professor Graeme Jones)
Author:Ding, C (Professor Chang-Hai Ding)
ID Code:66031
Year Published:2010
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-12-16
Last Modified:2011-10-31
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