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Meniscal extrusion predicts increases in subchondral bone marrow lesions and bone cysts and expansion of subchondral bone in osteoarthritic knees
Citation
Wang, Y and Wluka, AE and Pelletier, JP and Martel-Pelletier, J and Abram, F and Ding, C and Cicuttini, FM, Meniscal extrusion predicts increases in subchondral bone marrow lesions and bone cysts and expansion of subchondral bone in osteoarthritic knees, Rheumatology , 49, (5) pp. 997-1004. ISSN 1462-0324 (2010) [Refereed Article]
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The definitive publisher-authenticated version is available online at: http://www.oxfordjournals.org
Official URL: http://rheumatology.oxfordjournals.org/content/49/...
DOI: doi:10.1093/rheumatology/keq034
Abstract
Objectives. Meniscal extrusion is often present in knees with OA, and has been associated with cartilage
changes. It is unknown whether meniscal extrusion is related to subchondral bone. The aim of the study
was to examine the relationship between meniscal extrusion and knee cartilage and subchondral bone,
and also changes in these structures over 2 years in a cohort with mild to moderate knee OA.
Methods. One hundred and seventeen subjects with knee OA entered the study and underwent MRI on
their symptomatic knee at baseline and 2 years later. Meniscal extrusion was assessed at baseline; tibial
cartilage volume and plateau bone area, subchondral bone marrow lesions (BMLs) and bone cysts were
measured at baseline and follow-up.
Results. At baseline, meniscal extrusion was associated with reduced tibial cartilage volume, increased
tibial plateau area, increased prevalence of BMLs and bone cysts in both medial and lateral tibiofemoral
compartments (all P40.001). Baseline medial meniscal extrusion was associated with increased expansion
of tibial plateau bone (P = 0.04), increases in BMLs (P = 0.02) and bone cysts (P = 0.003) in the medial
tibiofemoral compartment over 2 years.
Conclusions. Meniscal extrusion predicts increases in subchondral bone lesions and tibial plateau bone
expansion in patients with knee OA. These data suggest that subchondral bone changes are an early
consequence of meniscal extrusion. This may reflect the impaired ability of an extruded meniscus to
optimally distribute mechanical loading across the tibial plateau.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Meniscal extrusion, Osteoarthritis, Bone, Bone marrow lesions, Bone cysts, Cartilage, Magnetic resonance imaging, Knee |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Clinical sciences |
| Research Field: | Rheumatology and arthritis |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Ding, C (Professor Chang-Hai Ding) |
| ID Code: | 66025 |
| Year Published: | 2010 |
| Web of Science® Times Cited: | 76 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2010-12-16 |
| Last Modified: | 2011-11-03 |
| Downloads: | 0 |
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