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Meniscal extrusion predicts increases in subchondral bone marrow lesions and bone cysts and expansion of subchondral bone in osteoarthritic knees

Citation

Wang, Y and Wluka, AE and Pelletier, JP and Martel-Pelletier, J and Abram, F and Ding, C and Cicuttini, FM, Meniscal extrusion predicts increases in subchondral bone marrow lesions and bone cysts and expansion of subchondral bone in osteoarthritic knees, Rheumatology , 49, (5) pp. 997-1004. ISSN 1462-0324 (2010) [Refereed Article]


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The definitive publisher-authenticated version is available online at: http://www.oxfordjournals.org

Official URL: http://rheumatology.oxfordjournals.org/content/49/...

DOI: doi:10.1093/rheumatology/keq034

Abstract

Objectives. Meniscal extrusion is often present in knees with OA, and has been associated with cartilage changes. It is unknown whether meniscal extrusion is related to subchondral bone. The aim of the study was to examine the relationship between meniscal extrusion and knee cartilage and subchondral bone, and also changes in these structures over 2 years in a cohort with mild to moderate knee OA. Methods. One hundred and seventeen subjects with knee OA entered the study and underwent MRI on their symptomatic knee at baseline and 2 years later. Meniscal extrusion was assessed at baseline; tibial cartilage volume and plateau bone area, subchondral bone marrow lesions (BMLs) and bone cysts were measured at baseline and follow-up. Results. At baseline, meniscal extrusion was associated with reduced tibial cartilage volume, increased tibial plateau area, increased prevalence of BMLs and bone cysts in both medial and lateral tibiofemoral compartments (all P40.001). Baseline medial meniscal extrusion was associated with increased expansion of tibial plateau bone (P = 0.04), increases in BMLs (P = 0.02) and bone cysts (P = 0.003) in the medial tibiofemoral compartment over 2 years. Conclusions. Meniscal extrusion predicts increases in subchondral bone lesions and tibial plateau bone expansion in patients with knee OA. These data suggest that subchondral bone changes are an early consequence of meniscal extrusion. This may reflect the impaired ability of an extruded meniscus to optimally distribute mechanical loading across the tibial plateau.

Item Details

Item Type:Refereed Article
Keywords:Meniscal extrusion, Osteoarthritis, Bone, Bone marrow lesions, Bone cysts, Cartilage, Magnetic resonance imaging, Knee
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Ding, C (Professor Chang-Hai Ding)
ID Code:66025
Year Published:2010
Web of Science® Times Cited:44
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-12-16
Last Modified:2011-11-03
Downloads:0

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