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Maternal antenatal peanut consumption and peanut and rye sensitization in the offspring at adolescence

Citation

Kemp, AS and Ponsonby, AL and Dwyer, T and Cochrane, JA and Pezic, A and Jones, G, Maternal antenatal peanut consumption and peanut and rye sensitization in the offspring at adolescence , Clinical and Experimental Allergy, 41, (2) pp. 224-231. ISSN 0954-7894 (2010) [Refereed Article]


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The definitive published version is available online at: http://onlinelibrary.wiley.com/

DOI: doi:10.1111/j.1365-2222.2010.03668.x

Abstract

Background There is considerable controversy whether maternal peanut ingestion during pregnancy might influence sensitization in later life. Objective To examine whether maternal peanut ingestion during pregnancy might increase sensitization in the offspring. Methods A population-based longitudinal cohort study with 16 years follow-up was conducted (N = 373). Subjects were recruited at birth as part of an infant health study. Maternal antenatal peanut consumption was documented at birth and peanut and rye sensitization were determined by measurement of serum-specific IgE at age 16. Results Peanut sensitization was common (14%). In the entire cohort (n = 310), there was no association between antenatal peanut ingestion and peanut sensitization (P = 0.17). However, there was a strong association between antenatal peanut ingestion and decreased risk of rye sensitization and peanut sensitization in those (n = 201) without a family history (FH) of asthma (Rye OR 0.30, 95% CI 0.14–0.63, P = 0.001 and Peanut OR 0.18, 95% CI 0.04–0.78, P = 0.02). There was an increased risk of rye sensitization in those (n = 108) with a FH of asthma and antenatal peanut ingestion (Rye OR 2.69, 95% CI 1.11–6.51 P = 0.03). It was considered that these sensitizations were likely to be related to the presence of IgE antibodies to cross-reacting carbohydrate epitopes common to rye and peanut allergens. Conclusions and Clinical Relevance Antenatal peanut ingestion may influence the development of IgE antibody to cross-reacting carbohydrate epitopes in later life. Genetic factors may modify this association.

Item Details

Item Type:Refereed Article
Keywords:adolescence, allergy, antenatal, cross reacting carbohydrate determinants, peanut, rye grass, sensitization
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Ponsonby, AL (Professor Anne Ponsonby)
Author:Dwyer, T (Professor Terry Dwyer)
Author:Cochrane, JA (Mrs Jennifer Cochrane)
Author:Jones, G (Professor Graeme Jones)
ID Code:66019
Year Published:2010
Web of Science® Times Cited:11
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-12-15
Last Modified:2011-05-02
Downloads:0

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