Maternal antenatal peanut consumption and peanut and rye sensitization in the offspring at adolescence
Kemp, AS and Ponsonby, AL and Dwyer, T and Cochrane, JA and Pezic, A and Jones, G, Maternal antenatal peanut consumption and peanut and rye sensitization in the offspring at adolescence , Clinical and Experimental Allergy, 41, (2) pp. 224-231. ISSN 0954-7894 (2010) [Refereed Article]
Background There is considerable controversy whether maternal peanut ingestion during
pregnancy might influence sensitization in later life.
Objective To examine whether maternal peanut ingestion during pregnancy might increase
sensitization in the offspring.
Methods A population-based longitudinal cohort study with 16 years follow-up was
conducted (N = 373). Subjects were recruited at birth as part of an infant health study.
Maternal antenatal peanut consumption was documented at birth and peanut and rye
sensitization were determined by measurement of serum-specific IgE at age 16.
Results Peanut sensitization was common (14%). In the entire cohort (n = 310), there was no
association between antenatal peanut ingestion and peanut sensitization (P = 0.17). However,
there was a strong association between antenatal peanut ingestion and decreased risk of rye
sensitization and peanut sensitization in those (n = 201) without a family history (FH) of
asthma (Rye OR 0.30, 95% CI 0.140.63, P = 0.001 and Peanut OR 0.18, 95% CI 0.040.78,
P = 0.02). There was an increased risk of rye sensitization in those (n = 108) with a FH of
asthma and antenatal peanut ingestion (Rye OR 2.69, 95% CI 1.116.51 P = 0.03). It was
considered that these sensitizations were likely to be related to the presence of IgE antibodies
to cross-reacting carbohydrate epitopes common to rye and peanut allergens.
Conclusions and Clinical Relevance Antenatal peanut ingestion may influence the
development of IgE antibody to cross-reacting carbohydrate epitopes in later life. Genetic
factors may modify this association.