eCite Digital Repository
Sex differences in the relationship between bone mineral density and tibial cartilage volume
Citation
Berry, PA and Wluka, AE and Davies-Tuck, ML and Wang, Y and Strauss, BJ and Dixon, JB and Proietto, J and Jones, G and Cicuttini, FM, Sex differences in the relationship between bone mineral density and tibial cartilage volume, Rheumatology, 50, (3) pp. 563-568. ISSN 1462-0324 (2011) [Refereed Article]
![]() | PDF Restricted - Request a copy 1Mb |
Copyright Statement
The definitive publisher-authenticated version is available online at: http://www.oxfordjournals.org
Official URL: http://www.oxfordjournals.org
DOI: doi:10.1093/rheumatology/keq341
Abstract
Objective. Although there is a well-established sex difference in the prevalence and severity of OA, the
mechanism for this is not clear. The aim of this study was to examine the potential role of BMD and BMC
in explaining gender differences in knee cartilage volume.
Methods. A total of 153 subjects aged 2560 years, 81% female, were recruited. MRI was performed
of the dominant knee. Cartilage volume was measured using validated methods. Total body BMD and
content was measured using DXA.
Results. Total body BMC and BMD was significantly associated with medial cartilage volume in both
sexes. However, the associations were stronger in men for BMC (B= 0.52; 95% CI 0.21, 0.83; P for
difference = 0.001) and BMD (B= 2242; 95% CI 443, 4041; P for difference = 0.05). Similar results were
obtained in the lateral tibial compartment. No significant association was obtained between total body
BMD and BMC and patella cartilage volume in either men or women.
Conclusions. In this relatively healthy population, we found a positive relationship between total body
BMD and BMC and tibial cartilage volume in the medial and lateral compartments. These relationships
were stronger in men than women. Thus, the results of this study may provide some insight into the sex
differences in knee cartilage volume, which may in turn facilitate our understanding of the pathogenesis
of OA.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | Sex differences, Bone mineral density, Cartilage volume |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Rheumatology and arthritis |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Jones, G (Professor Graeme Jones) |
ID Code: | 66015 |
Year Published: | 2011 |
Web of Science® Times Cited: | 8 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2010-12-15 |
Last Modified: | 2011-11-03 |
Downloads: | 0 |
Repository Staff Only: item control page