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Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study
Citation
Tanamas, SK and Wluka, AE and Pelletier, JP and Pelletier, JM and Abram, F and Berry, PA and Wang, Y and Jones, G and Cicuttini, FM, Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study , Rheumatology, 49, (12) pp. 2413-2419. ISSN 1462-0324 (2010) [Refereed Article]
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The definitive publisher-authenticated version is available online at: www.oxfordjournals.org
Official URL: http://rheumatology.oxfordjournals.org/content/49/...
DOI: doi:10.1093/rheumatology/keq286
Abstract
Objectives. The presence of bone marrow lesions (BMLs) has been linked to pain and progression of
knee OA. The aim of this study was to determine the relationship between BMLs and longitudinal change
in tibial cartilage volume and risk of knee joint replacement in subjects with knee OA.
Methods. One hundred and nine men and women with symptomatic knee OA were recruited. The same
knee was imaged using MRI at baseline and 2 years later. Tibial cartilage volume and BMLs were
measured. Knee joint replacement over 4 years was determined.
Results. The mean age of the subjects at baseline was 63.2 (S.D. 10.3) years. BMLs were present in
66% of the subjects. Cross-sectionally, BMLs were negatively associated with both medial (regression
coefficient 121.4; 95% CI 183.8, 859.1; P<0.001) and lateral (regression coefficient 142.1; 95% CI
241.8, 42.4; P = 0.01) tibial cartilage volume data. Longitudinally, for every 1-score increase in baseline
BML severity (range 04), the annual total tibial cartilage loss was increased by 1.14% (95% CI 0.29%,
1.87%; P = 0.01). The risk of knee joint replacement over 4 years increased with increasing BML score
(odds ratio 1.57; 95% CI 1.04, 2.35; P = 0.03).
Conclusion. The prevalence and severity of BMLs are associated with less tibial cartilage volume and
greater cartilage loss over 2 years. Moreover, severity of BMLs was positively associated with risk of knee
joint replacement over 4 years. This provides further support for the importance of BMLs in identifying
those with OA most likely to progress. Identifying factors that prevent or reduce the severity of BMLs may
provide an important target in the prevention of disease progression and treatment of OA, and the
subsequent need for arthroplasty.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Bone marrow lesions, Tibial cartilage, Cartilage loss, Knee joint replacement, Osteoarthritis |
| Research Division: | Medical and Health Sciences |
| Research Group: | Clinical Sciences |
| Research Field: | Rheumatology and Arthritis |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Skeletal System and Disorders (incl. Arthritis) |
| Author: | Jones, G (Professor Graeme Jones) |
| ID Code: | 66010 |
| Year Published: | 2010 |
| Web of Science® Times Cited: | 84 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2010-12-15 |
| Last Modified: | 2011-11-03 |
| Downloads: | 0 |
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