eCite Digital Repository

Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults

Citation

Stannus, OP and Jones, G and Cicuttini, F and Parameswaran, V and Quinn, S and Burgess, J and Ding, C, Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults, Osteoarthritis and Cartilage , 18, (11) pp. 1441-1447. ISSN 1063-4584 (2010) [Refereed Article]


Preview
PDF
Restricted - Request a copy
3Mb
  

Copyright Statement

The definitive version is available at http://www.sciencedirect.com

Official URL: http://www.sciencedirect.com

DOI: doi:10.1016/j.joca.2010.08.016

Abstract

Objective The role of inflammation in osteoarthritis (OA) pathogenesis is unclear, and the associations between inflammatory cytokines and cartilage loss have not been reported. We determined the associations between serum levels of interleukin (IL)-6 and tumor necrosis factor- (TNF-), knee radiographic OA (ROA) and cartilage loss over 2.9 years in older adults. Methods A total of 172 randomly selected subjects (mean 63 years, range 52C78, 47% female) were studied at baseline and approximately 3 (range 2.6C3.3) years later. IL-6 and TNF- were assessed by radioimmunoassay. T1-weighted fat-suppressed magnetic resonance imaging of the right knee was performed at baseline and follow-up to determine knee cartilage volume. Knee ROA of both knees was assessed at baseline. Results At baseline, quartiles of IL-6 and TNF- were associated with increased prevalence of medial tibiofemoral joint space narrowing (OARSI grade 1) in multivariate analyses [odds ratio (OR): 1.42 and 1.47 per quartile, respectively, both P < 0.05]. Longitudinally, baseline IL-6 predicted loss of both medial and lateral tibial cartilage volume (: −1.19% and −1.35% per annum per quartile, P < 0.05 and P < 0.01, respectively), independently of TNF-. Change in IL-6 was associated with increased loss of medial and lateral tibial cartilage volume (: −1.18% and −1.06% per annum per quartile, both P < 0.05) and change in TNF- was also negatively associated with change in medial cartilage volume (: −1.27% per annum per quartile, P < 0.05). Conclusions Serum levels of IL-6 and TNF- are associated with knee cartilage loss in older people suggesting low level inflammation plays a role in the pathogenesis of knee OA.

Item Details

Item Type:Refereed Article
Keywords:Osteoarthritis, Knee, Interleukin-6, TNF- Radiographic, MRI
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Stannus, OP (Mr Oliver Stannus)
Author:Jones, G (Professor Graeme Jones)
Author:Quinn, S (Dr Stephen Quinn)
Author:Burgess, J (Professor John Burgess)
Author:Ding, C (Professor Chang-Hai Ding)
ID Code:65928
Year Published:2010
Web of Science® Times Cited:137
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-12-09
Last Modified:2013-10-28
Downloads:0

Repository Staff Only: item control page