Schmidt, MD and Dwyer, T and Magnussen, CG and Venn, AJ, Predictive associations between alternative measures of childhood adiposity and adult cardio-metabolic health , International Journal of Obesity, 35, (1) pp. 38-45. ISSN 0307-0565 (2011) [Refereed Article]
Copyright © 2010 Nature Publishing Group
Official URL: http://www.nature.com/ijo/journal/v35/n1/full/ijo2...
Objective: To estimate associations between alternative measures of childhood adiposity and indicators of cardio-metabolic health in adulthood, both unadjusted and adjusted for changes in adiposity from childhood to adulthood.
Design and Methods: The study consisted of a 20-year follow-up of 2188 adults who had participated in the 1985 Australian Schools Health and Fitness Survey when they were between 7 and 15 years of age. Baseline and follow-up measures of body composition included height and weight, waist and hip circumferences and skinfold thicknesses at four sites. At follow-up, participants attended study clinics where component indicators of the metabolic syndrome (MetS) (waist circumference, blood pressure, fasting blood glucose and lipids) were measured.
Results: Waist circumference and skinfold measures were the strongest predictors of subsequent MetS (2009 Joint Scientific Statement definition) in early adulthood. For example, relative risks (RRs) for children in the highest (vs lowest) quarter of waist circumference were 4.8 (95% confidence interval (CI): 2.59.2) for males and 5.8 (95% CI: 2.414.2) for females. After adjusting for change in waist circumference from childhood to adulthood, each 10cm increase in childhood waist circumference was associated with an approximate twofold increase in risk for adult MetS (RR = 2.1 (95% CI: 1.72.7) among males and RR = 2.3 (95% CI: 1.63.4) among females).
Conclusion: Elevated waist circumference and skinfold thickness measures in childhood appear to be the strongest predictors of subsequent MetS in early adulthood. The increased risk associated with higher waist circumference in childhood appears to be independent of changes in waist circumference from childhood to adulthood.
|Item Type:||Refereed Article|
|Keywords:||childhood obesity; metabolic syndrome; measurement; longitudinal study|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Schmidt, MD (Dr Michael Schmidt)|
|Author:||Magnussen, CG (Dr Costan Magnussen)|
|Author:||Venn, AJ (Professor Alison Venn)|
|Web of Science® Times Cited:||55|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||3 View Download Statistics|
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