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Tracking of noninvasive ultrasound measurements of subclinical atherosclerosis in adulthood: Findings from the Cardiovascular Risk in Young Finns Study

Citation

Raiko, JRH and Magnussen, CG and Kahonen, M and Laitinen, T and Taittonen, L and Viikari, JSA and Raitakari, OT and Juonala, M, Tracking of noninvasive ultrasound measurements of subclinical atherosclerosis in adulthood: Findings from the Cardiovascular Risk in Young Finns Study, Ultrasound in Medicine and Biology, 36, (8) pp. 1237-1244. ISSN 0301-5629 (2010) [Refereed Article]


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DOI: doi:10.1016/j.ultrasmedbio.2010.05.003

Abstract

Abstract—We examined tracking of ultrasound measurements of vascular structure and function in adulthood using data collected in the 2001 and 2007 follow-ups of Cardiovascular Risk in Young Finns Study. B-mode ultrasound measures of carotid artery intima-media thickness (IMT), carotid artery distensibility (CDist) and brachial artery flow-mediated dilatation (FMD) was obtained on 1809 apparently healthy Finnish adults aged 24 to 39 years in 2001 (1014 females; 795 males). Significant 6-year tracking was observed for IMT (males, r 5 0.56; females, r 5 0.46), CDist (males, r 5 0.35; females, r 5 0.36) and FMD (males, r 5 0.23; females, r 5 0.20). Subjects with 10-year risk of CVD (according to the SCORE risk score) above sex-specific median had improved IMT (r 5 0.44; r 5 0.57, p 5 0.0001) and CDist (r 5 0.31; r 5 0.40, p 5 0.03) tracking compared with those below median. Body mass index (BMI) $ 30 kg/m2 decreased tracking of CDist (r 5 0.36; r 5 0.19, p 5 0.01). In conclusion, ultrasound measurements tracked low to moderate over 6-years and was influenced by cardiovascular disease (CVD) risk factor status.

Item Details

Item Type:Refereed Article
Keywords:Cardiovascular, Atherosclerosis, Ultrasound, Intima-media thickness, Carotid artery distensibility, Flow-mediated dilatation, Tracking
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Magnussen, CG (Dr Costan Magnussen)
ID Code:65737
Year Published:2010
Web of Science® Times Cited:6
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-12-01
Last Modified:2011-05-02
Downloads:0

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