Arterial structure and function after recovery from the Metabolic Syndrome - The cardiovascular risk in young Finns Study
Koskinen, J and Magnussen, CG and Taittonen, L and Rasanen, L and Mikkila, V and Laitinen, T and Ronnemaa, T and Kahonen, M and Viikari, JSA and Raitakari, OT and Juonala, M, Arterial structure and function after recovery from the Metabolic Syndrome - The cardiovascular risk in young Finns Study , Circulation , 121, (13) pp. 392-400. ISSN 0009-7322 (2010) [Refereed Article]
Background: The reversibility of ultrasonographic vascular changes associated with the metabolic syndrome (MetS)
recovery is unknown. We examined whether spontaneous recovery from MetS (according to the International Diabetes
Federation definition) has a favorable effect on vascular properties and evaluated the associations between lifestyle
factors and MetS recovery.
Methods and Results: We measured carotid artery intima-media thickness, distensibility, and brachial flow-mediated
dilatation by ultrasound in 1673 subjects of the Young Finns Study cohort (age, 31.55.0 years in 2001) who
participated in follow-up studies in 2001 and 2007. At baseline, no differences in intima-media thickness, carotid artery
distensibility, or flow-mediated dilatation were observed between the recovery group (baseline-only MetS) and those
with incident (only at follow-up) or persistent (both at baseline and follow-up) MetS. After 6 years, the recovery group
had smaller intima-media thickness (mean SEM, 0.62 0.01 versus 0.68 0.01 mm; P 0.0009) and higher carotid
artery distensibility (1.98 0.07%/mm Hg versus 1.56 0.04%/mm Hg; P0.001) compared with the persistent group
and higher flow-mediated dilatation compared with the control group (9.91 0.51% versus 8.57 0.12%; P0.03). The
recovery group had reduced intima-media thickness progression compared with the persistent group (0.036 0.005
versus 0.079 0.010 mm; P0.001) and reduced carotid artery distensibility change compared with the incident group
(0.12 0.05%/mm Hg versus 0.38 0.10%/mm Hg; P 0.03) over the 6-year follow-up. Differences in carotid
artery distensibility levels were attenuated (P 0.11) after the inclusion of weight change in the models. MetS recovery
was paralleled with significant reductions in waist circumference that independently correlated with increased physical
activity and increased attention paid to health habits during the follow-up.
Conclusion-Recovery from the MetS was associated with positive effects on vascular properties during a 6-year
follow-up period of young adults.