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Effect of high-dose nicotine patch on the characteristics of lapse episodes


Ferguson, SG and Shiffman, S, Effect of high-dose nicotine patch on the characteristics of lapse episodes, Health Psychology, 29, (4) pp. 358-366. ISSN 0278-6133 (2010) [Refereed Article]

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Copyright Statement

Copyright 2010 American Psychological Association

DOI: doi:10.1037/a0019367


Objective: Nicotine patch improves treatment outcomes, but lapses are still common. To understand the process of relapse on patch, we investigated differences in the antecedents (withdrawal, setting, triggers) of lapse episodes experienced on high-dose (35 mg) nicotine patches versus placebo. Design: Participants were smokers who lapsed during a randomized, double-blind trial of active patches (n = 100) versus placebo (n = 85). Participants used electronic diaries to monitor their smoking, affect, and activities in real time for 5 weeks during their cessation attempt. Results: We analyzed 490 lapse episodes (active: 266; placebo: 224). Lapses on nicotine patch were characterized by significantly lower positive affect and higher negative affect than placebo lapses. Participants treated with high-dose patch were also significantly more likely to lapse in situations involving little or no craving. Situational antecedents of lapses on patch resembled those on placebo. Conclusion: The results suggest that treatment with patch may set a higher threshold for affective stimuli to provoke lapses, but does not change the proximal cues that trigger lapses. This suggests that behavioral relapse-prevention strategies developed for unmedicated smokers should also apply to those treated with nicotine patch.

Item Details

Item Type:Refereed Article
Keywords:nicotine patch, lapse episodes, high dose, effect, withdrawal, tiggers, placebo, trial
Research Division:Psychology
Research Group:Applied and developmental psychology
Research Field:Psychology of ageing
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Behaviour and health
UTAS Author:Ferguson, SG (Professor Stuart Ferguson)
ID Code:65669
Year Published:2010
Web of Science® Times Cited:22
Deposited By:Pharmacy
Deposited On:2010-11-30
Last Modified:2011-04-17

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