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A prospective study of the associations between 25-hydroxy-vitamin D, sarcopenia progression and physical activity in older adults


Scott, D and Blizzard, L and Fell, J and Ding, C and Winzenberg, T and Jones, G, A prospective study of the associations between 25-hydroxy-vitamin D, sarcopenia progression and physical activity in older adults, Clinical Endocrinology, 73, (5) pp. 581-587. ISSN 0300-0664 (2010) [Refereed Article]

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DOI: doi:10.1111/j.1365-2265.2010.03858.x


Objective Low 25-hydroxyvitamin D (25OHD) levels may be associated with both sarcopenia (the age-related decline in muscle mass and function) and low physical activity (PA). Our objective was to describe prospective associations between 25OHD, muscle parameters, and PA in community-dwelling older adults. Design Prospective, population-based study with a mean followup of 26 04 years. Patients Six hundred and eighty-six community-dwelling older adults (49% women; mean SD 62 7 years old). Measurements Appendicular lean mass percentage (%ALM) and body fat assessed by Dual-energy X-ray Absorptiometry, leg strength by dynamometer, leg muscle quality (LMQ), PA assessed by pedometer, self-reported sun exposure by questionnaire, and serum 25OHD measured by radioimmunoassay. Results Participants with 25OHD 50 nm had lower mean %ALM, leg strength, LMQ and PA (all P < 005). As a continuous function, baseline 25OHD was a positive independent predictor of change in leg strength (b = 574 kg, 95% CI 065, 1082) and LMQ (b = 049 kg/kg, 95% CI 017, 082). Also, change in 25OHD was positively predicted by baseline %ALM (b = 203 pm/p.a., 95% CI 044, 362) leg strength (b = 030 pm/p.a., 95% CI 006, 053), LMQ (b = 448 pm/p.a., 95% CI 036, 861) and PA (b = 263 pm/ p.a., 95% CI 035, 492) after adjustment for sun exposure and body fat. Conclusions 25OHD may be important for the maintenance of muscle function, and higher skeletal muscle mass and function as well as general PA levels may also be beneficial for 25OHD status, in community-dwelling older adults.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Geriatrics and gerontology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Scott, D (Mr David Scott)
UTAS Author:Blizzard, L (Professor Leigh Blizzard)
UTAS Author:Fell, J (Associate Professor James Fell)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
UTAS Author:Winzenberg, T (Professor Tania Winzenberg)
UTAS Author:Jones, G (Professor Graeme Jones)
ID Code:65660
Year Published:2010
Web of Science® Times Cited:138
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-11-30
Last Modified:2011-05-02
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