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A prospective study of the associations between 25-hydroxy-vitamin D, sarcopenia progression and physical activity in older adults
Citation
Scott, D and Blizzard, L and Fell, J and Ding, C and Winzenberg, T and Jones, G, A prospective study of the associations between 25-hydroxy-vitamin D, sarcopenia progression and physical activity in older adults, Clinical Endocrinology, 73, (5) pp. 581-587. ISSN 0300-0664 (2010) [Refereed Article]
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Copyright Statement
The definitive published version is available online at: http://onlinelibrary.wiley.com/
Official URL: http://onlinelibrary.wiley.com/
DOI: doi:10.1111/j.1365-2265.2010.03858.x
Abstract
Objective Low 25-hydroxyvitamin D (25OHD) levels may be
associated with both sarcopenia (the age-related decline in muscle
mass and function) and low physical activity (PA). Our objective
was to describe prospective associations between 25OHD, muscle
parameters, and PA in community-dwelling older adults.
Design Prospective, population-based study with a mean followup
of 2Æ6 ± 0Æ4 years.
Patients Six hundred and eighty-six community-dwelling older
adults (49% women; mean ± SD 62 ± 7 years old).
Measurements Appendicular lean mass percentage (%ALM) and
body fat assessed by Dual-energy X-ray Absorptiometry, leg
strength by dynamometer, leg muscle quality (LMQ), PA assessed
by pedometer, self-reported sun exposure by questionnaire, and
serum 25OHD measured by radioimmunoassay.
Results Participants with 25OHD £50 nm had lower mean
%ALM, leg strength, LMQ and PA (all P < 0Æ05). As a continuous
function, baseline 25OHD was a positive independent predictor of
change in leg strength (b = 5Æ74 kg, 95% CI 0Æ65, 10Æ82) and LMQ
(b = 0Æ49 kg/kg, 95% CI 0Æ17, 0Æ82). Also, change in 25OHD was
positively predicted by baseline %ALM (b = 2Æ03 pm/p.a., 95% CI
0Æ44, 3Æ62) leg strength (b = 0Æ30 pm/p.a., 95% CI 0Æ06, 0Æ53),
LMQ (b = 4Æ48 pm/p.a., 95% CI 0Æ36, 8Æ61) and PA (b = 2Æ63 pm/
p.a., 95% CI 0Æ35, 4Æ92) after adjustment for sun exposure and body
fat.
Conclusions 25OHD may be important for the maintenance of
muscle function, and higher skeletal muscle mass and function as
well as general PA levels may also be beneficial for 25OHD status,
in community-dwelling older adults.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Medical and Health Sciences |
| Research Group: | Clinical Sciences |
| Research Field: | Geriatrics and Gerontology |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Skeletal System and Disorders (incl. Arthritis) |
| Author: | Scott, D (Mr David Scott) |
| Author: | Blizzard, L (Professor Leigh Blizzard) |
| Author: | Fell, J (Associate Professor James Fell) |
| Author: | Ding, C (Professor Chang-Hai Ding) |
| Author: | Winzenberg, T (Professor Tania Winzenberg) |
| Author: | Jones, G (Professor Graeme Jones) |
| ID Code: | 65660 |
| Year Published: | 2010 |
| Web of Science® Times Cited: | 71 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2010-11-30 |
| Last Modified: | 2011-05-02 |
| Downloads: | 1 View Download Statistics |
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