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Two-step stacking in capillary zone electrophoresis featuring sweeping and micelle to solvent stacking: I. Organic cations

Citation

Quirino, JP, Two-step stacking in capillary zone electrophoresis featuring sweeping and micelle to solvent stacking: I. Organic cations, Journal of Chromatography A, 1217, (49) pp. 7776-7780. ISSN 0021-9673 (2010) [Refereed Article]


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DOI: doi:10.1016/j.chroma.2010.10.020

Abstract

Two-step stacking of organic cations by sweeping and micelle to solvent stacking (MSS) in capillary zone electrophoresis (CZE) is presented. The simple procedure involves hydrodynamic injection of a micellar sodium dodecyl sulfate solution before the sample that is prepared without the micelles. The micelles sweep and transport the cations to the boundary zone between the sample and CZE buffer. The presence of organic solvent in the CZE buffer induces the second stacking step of MSS. The LODs obtained for the four beta blocker and two tricyclic antidepressant test drugs were 20–50 times better compared to typical injection.

Item Details

Item Type:Refereed Article
Keywords:On-line sample concentration; Sweeping; Micelle to solvent stacking; Capillary zone electrophoresis; Beta blocker drugs; Tricyclics antidepressant drugs
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Quirino, JP (Associate Professor Lito Quirino)
ID Code:65516
Year Published:2010
Web of Science® Times Cited:31
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2010-11-22
Last Modified:2014-10-17
Downloads:0

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