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Astrocytes in Alzheimer's Disease: Emerging Roles in Calcium Dysregulation and Synaptic Plasticity
Citation
Vincent, AJ and Gasperini, R and Foa, L and Small, DH, Astrocytes in Alzheimer's Disease: Emerging Roles in Calcium Dysregulation and Synaptic Plasticity, Journal of Alzheimer's Disease, 22, (3) pp. 699-714. ISSN 1387-2877 (2010) [Refereed Article]
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Copyright Statement
Copyright © 2010 IOS Press
Official URL: http://www.iospress.nl/authco/copyright.html
DOI: doi:10.3233/JAD-2010-101089
Abstract
Alzheimer’s disease (AD) is caused by the accumulation of amyloid
(A), which induces progressive decline in learning, memory, and other cognitive functions. A is a neurotoxic protein that disrupts calcium signaling in neurons and alters synaptic plasticity. These effects lead to loss of synapses, neural network dysfunction, and inactivation of neuronal signaling.
However, the precise mechanism by which A causes neurodegeneration is still not clear, despite decades of intensive research. The role of astrocytes in early cognitive decline is a major component of disease pathology that has been poorly understood. Recent research suggests that astrocytes are not simply passive support cells for neurons, but are active participants in neural
information processing in the brain. A can disrupt astrocytic calcium signaling and gliotransmitter release, processes that are vital for astrocyteneuron communication. Therefore, astrocyte dysfunction may contribute to the earliest neuronal deficits in AD. Here we discuss emerging concepts in glial biology and the implications of astrocyte dysfunction on neurodegeneration in AD.
Item Details
Item Type: | Refereed Article |
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Keywords: | Glia, gliotransmitters, homeostatic plasticity, network dysfunction, neural networks, neurodegeneration, seizures, TNFá |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Neurosciences not elsewhere classified |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Vincent, AJ (Dr Adele Vincent) |
UTAS Author: | Gasperini, R (Dr Rob Gasperini) |
UTAS Author: | Foa, L (Professor Lisa Foa) |
UTAS Author: | Small, DH (Professor David Small) |
ID Code: | 65209 |
Year Published: | 2010 |
Web of Science® Times Cited: | 63 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2010-10-13 |
Last Modified: | 2012-03-01 |
Downloads: | 4 View Download Statistics |
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