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Evidence for a common genetic aetiology in high-risk families with multiple haematological malignancy subtypes


Tegg, EM and Thomson, RJ and Stankovich, J and Banks, A and Flowers, C and McWhirter, R and Panton, J and Piaszczyk, A and Bahlo, M and Marsden, KA and Lowenthal, RM and Foote, SJ and Dickinson, JL, Evidence for a common genetic aetiology in high-risk families with multiple haematological malignancy subtypes , British Journal of Haematology, 150, (4) pp. 456-462. ISSN 0007-1048 (2010) [Refereed Article]

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DOI: doi:10.1111/j.1365-2141.2010.08267.x


A family history of a haematological malignancy (HM) is known to be a risk factor for HMs. However, collections of large families with multiple cases of varied disease types are relatively rare. We describe a collection of 12 families with dense aggregations of multiple HM subtypes. Cases were ascertained from a population based study conducted between 1972 and 1980 in Tasmania, Australia. Diagnoses were confirmed through review and re-examination of stored tissue, pathology reports, Tasmanian Cancer Registry and flow cytometry records. Family trees were generated and kinship coefficients were calculated for all pairs of affected individuals. 120 cases were found in these families. Cases diagnosed with chronic lymphocytic leukaemia (CLL) demonstrated the most significantly increased aggregation (P < 0Ζ0001). There was also significant evidence that those individuals diagnosed at an older age (>53 years), did not aggregate together in families with disease that presented at an earlier age (<20 years) (P = 0Ζ009).

Item Details

Item Type:Refereed Article
Keywords:familial haematological malignancy, aetiology, genetics
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Haematology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Tegg, EM (Dr Elizabeth Tegg)
UTAS Author:Thomson, RJ (Dr Russell Thomson)
UTAS Author:Stankovich, J (Dr Jim Stankovich)
UTAS Author:Banks, A (Mrs Annette Banks)
UTAS Author:Flowers, C (Mrs Ceri Flowers)
UTAS Author:McWhirter, R (Dr Rebekah McWhirter)
UTAS Author:Panton, J (Mrs Jean Panton)
UTAS Author:Piaszczyk, A (Mrs Anne Piaszczyk)
UTAS Author:Bahlo, M (Dr Melanie Bahlo)
UTAS Author:Marsden, KA (Dr Katherine Marsden)
UTAS Author:Lowenthal, RM (Professor Ray Lowenthal)
UTAS Author:Foote, SJ (Professor Simon Foote)
UTAS Author:Dickinson, JL (Professor Joanne Dickinson)
ID Code:65142
Year Published:2010
Web of Science® Times Cited:7
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-10-07
Last Modified:2011-05-02
Downloads:1 View Download Statistics

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