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Evidence for a common genetic aetiology in high-risk families with multiple haematological malignancy subtypes

Citation

Tegg, EM and Thomson, RJ and Stankovich, J and Banks, A and Flowers, C and McWhirter, R and Panton, J and Piaszczyk, A and Bahlo, M and Marsden, KA and Lowenthal, RM and Foote, SJ and Dickinson, JL, Evidence for a common genetic aetiology in high-risk families with multiple haematological malignancy subtypes , British Journal of Haematology, 150, (4) pp. 456-462. ISSN 0007-1048 (2010) [Refereed Article]


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The definitive published version is available online at: http://interscience.wiley.com

DOI: doi:10.1111/j.1365-2141.2010.08267.x

Abstract

A family history of a haematological malignancy (HM) is known to be a risk factor for HMs. However, collections of large families with multiple cases of varied disease types are relatively rare. We describe a collection of 12 families with dense aggregations of multiple HM subtypes. Cases were ascertained from a population based study conducted between 1972 and 1980 in Tasmania, Australia. Diagnoses were confirmed through review and re-examination of stored tissue, pathology reports, Tasmanian Cancer Registry and flow cytometry records. Family trees were generated and kinship coefficients were calculated for all pairs of affected individuals. 120 cases were found in these families. Cases diagnosed with chronic lymphocytic leukaemia (CLL) demonstrated the most significantly increased aggregation (P < 0Ζ0001). There was also significant evidence that those individuals diagnosed at an older age (>53 years), did not aggregate together in families with disease that presented at an earlier age (<20 years) (P = 0Ζ009).

Item Details

Item Type:Refereed Article
Keywords:familial haematological malignancy, aetiology, genetics
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Haematology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Tegg, EM (Dr Elizabeth Tegg)
Author:Thomson, RJ (Dr Russell Thomson)
Author:Stankovich, J (Dr Jim Stankovich)
Author:Banks, A (Mrs Annette Banks)
Author:Flowers, C (Mrs Ceri Flowers)
Author:McWhirter, R (Dr Rebekah McWhirter)
Author:Panton, J (Mrs Jean Panton)
Author:Piaszczyk, A (Mrs Anne Piaszczyk)
Author:Bahlo, M (Dr Melanie Bahlo)
Author:Marsden, KA (Dr Katherine Marsden)
Author:Lowenthal, RM (Professor Ray Lowenthal)
Author:Foote, SJ (Professor Simon Foote)
Author:Dickinson, JL (Associate Professor Joanne Dickinson)
ID Code:65142
Year Published:2010
Web of Science® Times Cited:6
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-10-07
Last Modified:2011-05-02
Downloads:1 View Download Statistics

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