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Oral contraceptive use and bone mass in women aged 26-36 years
Citation
Wei, S and Jones, G and Thomson, R and Dwyer, T and Venn, A, Oral contraceptive use and bone mass in women aged 26-36 years, Osteoporosis International, 22, (1) pp. 351-355. ISSN 0937-941X (2011) [Refereed Article]
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Copyright Statement
The original publication is available at www.springerlink.com
Official URL: http://www.springerlink.com
DOI: doi:10.1007/s00198-010-1180-y
Abstract
Introduction
The association between hormonal contraceptive use and bone mineral density remains controversial.
Hypothesis
Hormonal contraceptive use is positively associated with bone mass in young premenopausal women.
Methods
Cross-sectional analysis of data collected from women aged 2636 years (n = 687) in the Childhood Determinants of Adult Health studya longitudinal study investigating childhood determinants of cardiovascular disease, diabetes, and other chronic diseases in adulthood. Participants were not currently pregnant or breast-feeding. Contraceptive use was obtained by self-administered questionnaire. Women were categorized as combined oral contraceptive users (n = 219), progestogen-only contraceptive users (n = 43), and non-users of hormonal contraceptives (n = 425). Bone mass was measured by quantitative ultrasound.
Results
Compared with women who were not using any hormonal contraceptives, women using combined oral contraceptives had significantly higher values of broadband ultrasound attenuation (BUA), speed of sound, and quantitative ultrasound index. These associations remained after adjustment for confounders. Progestogen-only contraceptive users had higher BUA than non-users, but the differences were not statistically significant in this small group.
Conclusion
Combined oral contraceptive use was associated with higher bone mass measured by quantitative ultrasound in this population-based sample of premenopausal women aged 2636 while progestogen-only contraceptives appeared to have no deleterious effect on bone mass.
Item Details
Item Type: | Refereed Article |
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Keywords: | Bone mass, Contraceptive, Oral contraceptive, Population, Progestogen, Quantitative ultrasound, Young women |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Rheumatology and arthritis |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Wei, S (Mrs Shuying Wei) |
UTAS Author: | Jones, G (Professor Graeme Jones) |
UTAS Author: | Thomson, R (Dr Russell Thomson) |
UTAS Author: | Venn, A (Professor Alison Venn) |
ID Code: | 64939 |
Year Published: | 2011 |
Web of Science® Times Cited: | 9 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2010-09-16 |
Last Modified: | 2012-03-19 |
Downloads: | 3 View Download Statistics |
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