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The relationship between body composition and structural changes at the knee
Citation
Berry, PA and Wluka, AE and Davies-Tuck, ML and Wang, Y and Strauss, BJ and Dixon, JB and Proietto, J and Jones, G and Cicuttini, FM, The relationship between body composition and structural changes at the knee, Rheumatology, 49, (12) pp. 2362-2369. ISSN 1462-0324 (2010) [Refereed Article]
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The definitive publisher-authenticated version is available online at: http://www.oxfordjournals.org/
Official URL: http://www.oxfordjournals.org
DOI: doi:10.1093/rheumatology/keq255
Abstract
Objective. Obesity is an important risk factor for knee OA. Evidence suggests that fat and muscle have differential effects on the pathogenesis of disease. The aim of this study was to examine the relationship between body composition and knee structure, including knee cartilage volume, defects and bone marrow
lesions (BMLs).
Methods. A total of 153 subjects aged 2560 years, 81% females, were recruited across a range of BMI(1855 kg/m2) for a study examining the relationship between obesity and musculoskeletal disease. MRI was performed of the dominant knee. Cartilage volume, defects and BMLs were measured using validated
methods. Body composition was measured using dual X-ray absorptiometry.
Results. There was an 81 (95% CI: 69, 94) mm3 increase in cartilage volume for every 1 kg increase in skeletal muscle mass. Fat mass was not significantly associated with cartilage volume. Fat mass, but not skeletal muscle mass, was a risk factor for cartilage defects and BMLs. For every 1 kg increase in total
body fat there was an increased risk of cartilage defects (OR = 1.31, 95% CI: 1.04, 1.64) and BMLs (OR = 1.09, 95% CI: 1.01, 1.18).
Conclusions. In this relatively healthy population, fat mass was associated with increased cartilage defects and BMLs, which are features of early knee OA. In contrast, skeletal muscle mass was positively associated with cartilage volume, which may be due to coinheritance, a commonality of environmental
factors associated with cartilage accrual or a protective effect of increased muscle.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Osteoarthritis, Obesity, MRI, Bone marrow lesions, Cartilage |
| Research Division: | Medical and Health Sciences |
| Research Group: | Clinical Sciences |
| Research Field: | Rheumatology and Arthritis |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Skeletal System and Disorders (incl. Arthritis) |
| Author: | Jones, G (Professor Graeme Jones) |
| ID Code: | 64904 |
| Year Published: | 2010 |
| Web of Science® Times Cited: | 33 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2010-09-15 |
| Last Modified: | 2011-11-03 |
| Downloads: | 0 |
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