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Age-related anabolic resistance after endurance-type exercise in healthy humans
Citation
Durham, WJ and Casperson, SL and Dillon, EL and Keske, MA and Paddon-Jones, D and Sanford, AP and Hickner, RC and Grady, JJ and Sheffield-Moore, M, Age-related anabolic resistance after endurance-type exercise in healthy humans, The FASEB Journal: (Federation of American Societies for Experimental Biology), 24, (10) pp. 4117-4127. ISSN 0892-6638 (2010) [Refereed Article]
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Copyright Statement
Copyright © 2010 by The Federation of American Societies for Experimental Biology.
Official URL: http://www.fasebj.org/misc/copyright.shtml
Abstract
Age-related skeletal muscle loss is thought
to stem from suboptimal nutrition and resistance to
anabolic stimuli. Impaired microcirculatory (nutritive)
blood flow may contribute to anabolic resistance by
reducing delivery of amino acids to skeletal muscle. In
this study, we employed contrast-enhanced ultrasound,
microdialysis sampling of skeletal muscle interstitium,
and stable isotope methodology, to assess hemodynamic
and metabolic responses of older individuals to
endurance type (walking) exercise during controlled
amino acid provision. We hypothesized that older individuals
would exhibit reduced microcirculatory blood
flow, interstitial amino acid concentrations, and amino
acid transport when compared with younger controls.
We report for the first time that aging induces anabolic
resistance following endurance exercise, manifested as
reduced (by 40%) efficiency of muscle protein synthesis.
Despite lower (by 4045%) microcirculatory
flow in the older than in the younger participants,
circulating and interstitial amino acid concentrations
and phenylalanine transport into skeletal muscle were
all equal or higher in older individuals than in the
young, comprehensively refuting our hypothesis that
amino acid availability limits postexercise anabolism in
older individuals. Our data point to alternative mediators
of age-related anabolic resistance and importantly
suggest correction of these impairments may reduce
requirements for, and increase the efficacy of, dietary
protein in older individuals. Durham, W. J., Casperson,
S. L., Dillon, E. L., Keske, M. A., Paddon-Jones, D.,
Sanford, A. P., Hickner, R. C., Grady, J. J., Sheffield-
Moore, M. Age-related anabolic resistance after endurance-
type exercise in healthy humans.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | amino acids; blood flow; microdialysis ethanol; contrast-enhanced ultrasound; microcirculation |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Medical biochemistry and metabolomics |
Research Field: | Medical biochemistry - amino acids and metabolites |
Objective Division: | Health |
Objective Group: | Specific population health (excl. Indigenous health) |
Objective Field: | Health related to ageing |
UTAS Author: | Keske, MA (Dr Michelle Keske) |
ID Code: | 64890 |
Year Published: | 2010 |
Web of Science® Times Cited: | 62 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2010-09-14 |
Last Modified: | 2011-04-29 |
Downloads: | 0 |
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