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The role of TNF in parasitic diseases: Still more questions than answers


Korner, H and McMorran, B and Schluter, D and Fromm, P, The role of TNF in parasitic diseases: Still more questions than answers, International Journal for Parasitology, 40, (8) pp. 879-888. ISSN 0020-7519 (2010) [Refereed Article]

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DOI: doi:10.1016/j.ijpara.2010.03.011


The inhibition of TNF with therapeutic monoclonal antibodies or antibody/receptor fusion proteins in rheumatoid arthritis still constitutes the benchmark for a successful intervention in an ongoing autoimmune- inflammatory disease and underlines the importance of this cytokine. TNF plays a central role in the defence against intracellular infections and is responsible for the promotion of different aspects of the innate immune response such as inflammatory cell recruitment and cell differentiation. While this cytokine generally displays pro-inflammatory activities supporting the early stages of the inflammatory response, it has been demonstrated to be especially important during infection with intracellular pathogens and, consequently, leishmaniasis of TNF!/! mice ends fatally. However, the specific activities of TNF that confer protection are not yet fully understood. This review will summarize the current understanding of TNF function and signalling, and will discuss recent work in the models of malaria, toxoplasmosis, trypanosomiasis and leishmaniasis with particular emphasis on work with gene-deficient mouse models.

Item Details

Item Type:Refereed Article
Keywords:Tumor necrosis factor, Knockout models, Malaria, Toxoplasmosis, Trypanosomiasis, Leishmaniasis
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Infectious diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Korner, H (Professor Heinrich Korner)
UTAS Author:McMorran, B (Associate Professor Brendan McMorran)
ID Code:64858
Year Published:2010
Web of Science® Times Cited:32
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-09-08
Last Modified:2015-02-05
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