eCite Digital Repository

Presenilins and the gamma-secretase: still a complex problem

Citation

Small, DH and Klaver, DW and Foa, L, Presenilins and the gamma-secretase: still a complex problem, Molecular Brain, 3, (1) pp. 1-6. ISSN 1756-6606 (2010) [Refereed Article]


Preview
PDF
345Kb
  

Copyright Statement

© 2010 Small et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI: doi:10.1186/1756-6606-3-7

Abstract

The presenilins form part of a complex of membrane proteins that are involved in the proteolytic cleavage of cellsurface molecules. This article reviews the history of the discovery of the presenilins, their role in the pathogenesis of Alzheimer’s disease and in the metabolism of the amyloid-b precursor protein. Unanswered questions about their biochemical mechanism of action and their effects on Ca2+ homeostasis are examined.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
Author:Small, DH (Professor David Small)
Author:Klaver, DW (Mr David Klaver)
Author:Foa, L (Professor Lisa Foa)
ID Code:64854
Year Published:2010
Web of Science® Times Cited:18
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-09-07
Last Modified:2012-03-06
Downloads:253 View Download Statistics

Repository Staff Only: item control page