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Human Leukocyte Antigen-DR15, Low Infant Sibling Exposure and Multiple Sclerosis: Gene-Environment Interaction

journal contribution
posted on 2023-05-17, 03:08 authored by Ingrid van der MeiIngrid van der Mei, Ponsonby, AL, Bruce TaylorBruce Taylor, Jim Stankovich, Joanne DickinsonJoanne Dickinson, Simon James FooteSimon James Foote, Kemp, A, Terry DwyerTerry Dwyer
The risk for development of multiple sclerosis has been associated with human leukocyte antigen- DRB1*1501-DQB1*0602 (HLA-DR15) genotype, low infant sibling exposure, and high Epstein-Barr nuclear antigen IgG levels. In a population-based case-control study (Tasmania, Australia), we found that the combined effect of HLA-DR15 positivity and low infant sibling exposure on multiple sclerosis (odds ratio, 7.88; 95% confidence interval, 3.43-18.11) was 3.9- fold greater than expected (test for interaction, p 0.019) This interaction was observed irrespective of Epstein-Barr nuclear antigen IgG levels. This suggests that immune mechanisms involving HLA class II molecules are susceptible to modulation in early life.

History

Publication title

Annals of Neurology

Volume

67

Pagination

261-265

ISSN

0364-5134

Department/School

Menzies Institute for Medical Research

Publisher

Wiley-Liss

Place of publication

Div John Wiley & Sons Inc, 605 Third Ave, New York, USA, Ny, 10158-0012

Rights statement

The definitive published version is available online at: http://interscience.wiley.com

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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    University Of Tasmania

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