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Human Leukocyte Antigen-DR15, Low Infant Sibling Exposure and Multiple Sclerosis: Gene-Environment Interaction
journal contribution
posted on 2023-05-17, 03:08 authored by Ingrid van der MeiIngrid van der Mei, Ponsonby, AL, Bruce TaylorBruce Taylor, Jim Stankovich, Joanne DickinsonJoanne Dickinson, Simon James FooteSimon James Foote, Kemp, A, Terry DwyerTerry DwyerThe risk for development of multiple sclerosis has been associated with human leukocyte antigen- DRB1*1501-DQB1*0602 (HLA-DR15) genotype, low infant sibling exposure, and high Epstein-Barr nuclear antigen IgG levels. In a population-based case-control study (Tasmania, Australia), we found that the combined effect of HLA-DR15 positivity and low infant sibling exposure on multiple sclerosis (odds ratio, 7.88; 95% confidence interval, 3.43-18.11) was 3.9- fold greater than expected (test for interaction, p 0.019) This interaction was observed irrespective of Epstein-Barr nuclear antigen IgG levels. This suggests that immune mechanisms involving HLA class II molecules are susceptible to modulation in early life.
History
Publication title
Annals of NeurologyVolume
67Pagination
261-265ISSN
0364-5134Department/School
Menzies Institute for Medical ResearchPublisher
Wiley-LissPlace of publication
Div John Wiley & Sons Inc, 605 Third Ave, New York, USA, Ny, 10158-0012Rights statement
The definitive published version is available online at: http://interscience.wiley.comRepository Status
- Restricted