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Human Leukocyte Antigen-DR15, Low Infant Sibling Exposure and Multiple Sclerosis: Gene-Environment Interaction


van der Mei, IAF and Ponsonby, AL and Taylor, BV and Stankovich, J and Dickinson, JL and Foote, S and Kemp, A and Dwyer, T, Human Leukocyte Antigen-DR15, Low Infant Sibling Exposure and Multiple Sclerosis: Gene-Environment Interaction, Annals of Neurology, 67, (2) pp. 261-265. ISSN 0364-5134 (2010) [Refereed Article]

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DOI: doi:10.1002/ana.21849


The risk for development of multiple sclerosis has been associated with human leukocyte antigen- DRB1*1501-DQB1*0602 (HLA-DR15) genotype, low infant sibling exposure, and high Epstein–Barr nuclear antigen IgG levels. In a population-based case–control study (Tasmania, Australia), we found that the combined effect of HLA-DR15 positivity and low infant sibling exposure on multiple sclerosis (odds ratio, 7.88; 95% confidence interval, 3.43–18.11) was 3.9- fold greater than expected (test for interaction, p  0.019) This interaction was observed irrespective of Epstein–Barr nuclear antigen IgG levels. This suggests that immune mechanisms involving HLA class II molecules are susceptible to modulation in early life.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurology and Neuromuscular Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:van der Mei, IAF (Associate Professor Ingrid van der Mei)
Author:Ponsonby, AL (Professor Anne Ponsonby)
Author:Taylor, BV (Professor Bruce Taylor)
Author:Stankovich, J (Dr Jim Stankovich)
Author:Dickinson, JL (Associate Professor Joanne Dickinson)
Author:Foote, S (Professor Simon Foote)
Author:Dwyer, T (Professor Terry Dwyer)
ID Code:64843
Year Published:2010
Web of Science® Times Cited:16
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-09-07
Last Modified:2012-04-20

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