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Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain

Citation

Howells, C and West, AK and Chung, RS, Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain , The F E B S Journal, 277, (14) pp. 2931-2939. ISSN 1742-464X (2010) [Refereed Article]


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The definitive published version is available online at: http://interscience.wiley.com

DOI: doi:10.1111/j.1742-4658.2010.07718.x

Abstract

Neuronal growth-inhibitory factor, later renamed metallothionein-3, is one of four members of the mammalian metallothionein family. Metallothioneins are a family of ubiquitous, low-molecular-weight, cysteine-rich proteins. Although neuronal growth-inhibitory factor shares metal-binding and reactive oxygen species scavenging properties with the other metallothioneins, it displays several distinct biological properties. In this review, we examine the recent developments regarding the function of neuronal growth-inhibitory factor within the brain, particularly in response to brain injury or during neurodegenerative disease progression.

Item Details

Item Type:Refereed Article
Keywords:brain injury; metals; neuronal growth-inhibitory factor (GIF); neurodegenerative disease; oxidative stress
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Cellular Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Howells, C (Ms Claire Howells)
Author:West, AK (Professor Adrian West)
Author:Chung, RS (Associate Professor Roger Chung)
ID Code:64817
Year Published:2010
Web of Science® Times Cited:22
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-09-02
Last Modified:2012-02-21
Downloads:0

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