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Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain
Citation
Howells, C and West, AK and Chung, RS, Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain , The F E B S Journal, 277, (14) pp. 2931-2939. ISSN 1742-464X (2010) [Refereed Article]
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Copyright Statement
The definitive published version is available online at: http://interscience.wiley.com
DOI: doi:10.1111/j.1742-4658.2010.07718.x
Abstract
Neuronal growth-inhibitory factor, later renamed metallothionein-3, is one
of four members of the mammalian metallothionein family. Metallothioneins
are a family of ubiquitous, low-molecular-weight, cysteine-rich proteins.
Although neuronal growth-inhibitory factor shares metal-binding and reactive
oxygen species scavenging properties with the other metallothioneins,
it displays several distinct biological properties. In this review, we examine
the recent developments regarding the function of neuronal growth-inhibitory
factor within the brain, particularly in response to brain injury or
during neurodegenerative disease progression.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | brain injury; metals; neuronal growth-inhibitory factor (GIF); neurodegenerative disease; oxidative stress |
| Research Division: | Medical and Health Sciences |
| Research Group: | Neurosciences |
| Research Field: | Cellular Nervous System |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Nervous System and Disorders |
| Author: | Howells, C (Ms Claire Howells) |
| Author: | West, AK (Professor Adrian West) |
| Author: | Chung, RS (Associate Professor Roger Chung) |
| ID Code: | 64817 |
| Year Published: | 2010 |
| Web of Science® Times Cited: | 24 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2010-09-02 |
| Last Modified: | 2012-02-21 |
| Downloads: | 0 |
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