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Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways
journal contribution
posted on 2023-05-17, 03:07 authored by Jacqueline LeungJacqueline Leung, Pankhurst, M, Dunlop, SA, Shannon HuskinsShannon Huskins, Dittmann, J, Eaton, ED, Palumaa, P, Sillard, R, Meng Inn ChuahMeng Inn Chuah, Adrian WestAdrian West, Chung, RSFollowing central nervous system injury, astrocytes rapidly respond by undergoing a stereotypical pattern of molecular and morphological alterations termed “reactive” astrogliosis. We have reported previously that metallothioneins (MTs) are rapidly expressed by reactive astrocytes and that their secretion and subsequent interaction with injured neurons leads to improved neuroregeneration. We now demonstrate that exogenous MT induces a reactive morphology and elevated GFAP expression in cultured astrocytes. Furthermore, these astrogliotic hallmarks were mediated via JAK/STAT and RhoA signalling pathways. However, rather than being inhibitory, MT induced a form of astrogliosis that was permissive to neurite outgrowth and which was associated with decreased chondroitin sulphate proteoglycan (CSPG) expression. The results suggest that MT has an important role in mediating permissive astrocytic responses to traumatic brain injury.
History
Publication title
Experimental Neurology: A Journal of Neuroscience ResearchVolume
221Pagination
98-106ISSN
0014-4886Department/School
Menzies Institute for Medical ResearchPublisher
Academic Press Inc Elsevier SciencePlace of publication
525 B St, Ste 1900, San Diego, USA, Ca, 92101-4495Rights statement
The definitive version is available at http://www.sciencedirect.comRepository Status
- Restricted