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Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus

Citation

Miller, RD and Hogg, J and Ozaki, JH and Gell, D and Jackson, SP and Riblet, R, Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus, National Academy of Sciences of The United States of America. Proceedings, 92, (23) pp. 10792-10795. ISSN 0027-8424 (1995) [Refereed Article]

DOI: doi:10.1073/pnas.92.23.10792

Abstract

The gene encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PK(cs)) has been proposed recently as a candidate gene for the mouse severe combined immune deficiency (scid) locus. We have used a partial cDNA clone for human DNA-PK(cs) to map the mouse homologue using a large interspecific backcross panel. We found that the mouse gene for DNA-PK(cs) does not recombine with scid, consistent with the hypothesis that scid is a mutation in the mouse gene for DNA-PK(cs).

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Biochemistry and Cell Biology
Research Field:Enzymes
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Biological Sciences
Author:Gell, D (Dr David Gell)
ID Code:64595
Year Published:1995
Web of Science® Times Cited:49
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-08-12
Last Modified:2011-08-25
Downloads:0

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