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Ikaros: a key regulator of haematopoiesis

Citation

Westman, BJ and Mackay, JP and Gell, D, Ikaros: a key regulator of haematopoiesis, International Journal of Biochemistry and Cell Biology, 34, (10) pp. 1304-1307. ISSN 1357-2725 (2002) [Refereed Article]

DOI: doi:10.1016/S1357-2725(02)00070-5

Abstract

Ikaros is an essential transcription factor for normal lymphocyte development. Because of its interaction with a number of closely related factors, Ikaros is required for correct regulation of differentiation and cell proliferation in T- and B-cell lineages. Interestingly, Ikaros appears to function both as a transcriptional repressor and as an activator through its ability to bind a large number of nuclear factors, including components of both histone deacetylase and ATP-dependent chromatin remodelling complexes. In addition, nuclear localisation is important for Ikaros function - unlike most transcription factors, Ikaros is localised to discrete nuclear foci in lymphoid cells, suggesting it employs novel mechanisms to regulate transcription. © 2002 Elsevier Science Ltd. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Biochemistry and Cell Biology
Research Field:Structural Biology (incl. Macromolecular Modelling)
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Biological Sciences
Author:Gell, D (Dr David Gell)
ID Code:64556
Year Published:2002
Web of Science® Times Cited:18
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-08-12
Last Modified:2011-08-02
Downloads:0

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