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blaROB-1 Location on pB1000 in Haemophilus influenzae is widespread and variable cefaclor resistance is associated with altered penicillin-binding proteins
Citation
Tristram, SG and Littlejohn, R and Bradbury, RS, blaROB-1 Location on pB1000 in Haemophilus influenzae is widespread and variable cefaclor resistance is associated with altered penicillin-binding proteins, Antimicrobial Agents and Chemotherapy, 54, (11) pp. 4945-4947. ISSN 0066-4804 (2010) [Refereed Article]
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Copyright Statement
Copyright © 2010, American Society for Microbiology.
Official URL: http://aac.asm.org/
Abstract
Plasmid pB1000 is a small replicon recently identified as bearing blaROB-1 in animal and human Pasteurellaceae in Spain. We identified pB1000 in 11 blaROB-1-positive Australian and North American Haemophilus influenzae isolates, suggesting a wider role for pB1000 in disseminating blaROB-1. Native H. influenzae conjugative elements can mobilize plasmids similar to pB1000 at a low frequency of 10–8, and this might account for the infrequency of blaROB-1 compared to the rate of occurrence of blaTEM-1. Altered penicillin-binding protein 3 was associated with an increased cefaclor MIC in 3 isolates.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Medical microbiology |
| Research Field: | Medical bacteriology |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Tristram, SG (Dr Stephen Tristram) |
| UTAS Author: | Littlejohn, R (Miss Rachael Littlejohn) |
| UTAS Author: | Bradbury, RS (Dr Richard Bradbury) |
| ID Code: | 64546 |
| Year Published: | 2010 |
| Web of Science® Times Cited: | 12 |
| Deposited By: | Medicine |
| Deposited On: | 2010-08-12 |
| Last Modified: | 2014-11-25 |
| Downloads: | 378 View Download Statistics |
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