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blaROB-1 Location on pB1000 in Haemophilus influenzae is widespread and variable cefaclor resistance is associated with altered penicillin-binding proteins

Citation

Tristram, SG and Littlejohn, R and Bradbury, RS, blaROB-1 Location on pB1000 in Haemophilus influenzae is widespread and variable cefaclor resistance is associated with altered penicillin-binding proteins, Antimicrobial Agents and Chemotherapy, 54, (11) pp. 4945-4947. ISSN 0066-4804 (2010) [Refereed Article]


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Copyright Statement

Copyright 2010, American Society for Microbiology.

Official URL: http://aac.asm.org/

DOI: doi:10.1128/AAC.00263-10

Abstract

Plasmid pB1000 is a small replicon recently identified as bearing blaROB-1 in animal and human Pasteurellaceae in Spain. We identified pB1000 in 11 blaROB-1-positive Australian and North American Haemophilus influenzae isolates, suggesting a wider role for pB1000 in disseminating blaROB-1. Native H. influenzae conjugative elements can mobilize plasmids similar to pB1000 at a low frequency of 108, and this might account for the infrequency of blaROB-1 compared to the rate of occurrence of blaTEM-1. Altered penicillin-binding protein 3 was associated with an increased cefaclor MIC in 3 isolates.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Medical Microbiology
Research Field:Medical Bacteriology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Tristram, SG (Dr Stephen Tristram)
Author:Littlejohn, R (Miss Rachael Littlejohn)
Author:Bradbury, RS (Dr Richard Bradbury)
ID Code:64546
Year Published:2010
Web of Science® Times Cited:10
Deposited By:Medicine (Discipline)
Deposited On:2010-08-12
Last Modified:2014-11-25
Downloads:287 View Download Statistics

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