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Reversing Aberrant Methylation Patterns in Cancer


Poke, FS and Qadi, A and Holloway, AF, Reversing Aberrant Methylation Patterns in Cancer, Current Medicinal Chemistry, 17, (13) pp. 1246-1254. ISSN 0929-8673 (2010) [Refereed Article]

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© 2010 Bentham Science Publishers Ltd.

DOI: doi:10.2174/092986710790936329


Changes to the epigenetic information within a cell play a significant role in cancer development and progression. These epigenetic changes are important in establishing the aberrant gene expression patterns that are a feature of cancer cell biology. We are currently experiencing a rapid advance in our understanding of how epigenetic information is written and interpreted in the cell, and the enzymes involved in these processes have been recognised as prime targets for therapeutic intervention. Reagents that target these enzymes have the potential to inhibit or reverse epigenetic changes in cancer cells. Evidence suggests that the aberrant regulation of two gene silencing pathways; involving DNA methylation and histone methylation, play an important role in cancer development. Considerable effort is being exerted in the development of inhibitors of these pathways. However, complex functional interactions exist between the DNA and histone methylation pathways, and these interactions will need to be considered in the design of inhibitory molecules. This review details current research into agents developed as inhibitors of these epigenetic pathways, focusing on the types of epigenetic modifications being targeted, interactions between these modifications and the use of these inhibitory agents in cancer treatment.

Item Details

Item Type:Refereed Article
Keywords:epigenetic, DNA methylation, histone methylation, cancer
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Cancer genetics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Poke, FS (Dr Fiona Poke)
UTAS Author:Qadi, A (Ms Abeer Qadi)
UTAS Author:Holloway, AF (Professor Adele Holloway)
ID Code:64518
Year Published:2010
Web of Science® Times Cited:10
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-08-10
Last Modified:2014-01-02

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