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Caudwell Xtreme Everest: a field study of human adaptation to hypoxia

Citation

Grocott, M and Richardson, A and Montgomery, H and Mythen, M and Ahuja, V and Aref-Adib, G and Burnham, R and Chisholm, A and Clarke, K and Coates, D and Coates, M and Cook, D and Cox, M and Dhillon, S and Dougall, C and Doyle, P and Duncan, P and Edsell, M and Edwards, LM and Evans, L and Gardiner, P and Gunning, P and Hart, N and Harrington, J and Harvey, J and Holloway, C and Howard, D and Hurlbut, D and Imray, C and Ince, C and Jonas, M and van der Kaaij, J and Khosravi, M and Kolfschoten, N and Levett, D and Luery, H and Luks, A and Martin, D and McMorrow, R and Meale, P and Mitchell, K and Morgan, G and Morgan, J and Murray, A and Newman, S and O'Dwyer, M and Pate, J and Plant, T and Pun, M and Richards, P and Rodway, G and Simpson, J and Stroud, C and Stroud, M and Stygal, J and Symons, B and Szawarski, P and Van Tulleken, A and Van Tulleken, C and Vercueil, A and Wandrag, L and Wilson, M and Windsor, J, Caudwell Xtreme Everest: a field study of human adaptation to hypoxia, Critical Care, 11, (4) EJ ISSN 1466-609X (2007) [Refereed Article]

DOI: doi:10.1186/cc5921

Abstract

Caudwell Xtreme Everest (CXE) is a large healthy volunteer field study investigating human adaptation to environmental hypoxia. More than 200 individuals were studied at sea-level and in four laboratories on the trek to Everest Base Camp (5,300 m). Fifteen physicians climbed high on Everest and continued the studies as they ascended; eight of these individuals reached the summit of Everest and succeeded in sampling arterial blood at 8,400 m on their descent. Core measurements included cardiopulmonary exercise testing, neuropsychological assessment, near infra-red spectroscopy of brain and exercising muscle, blood markers and daily recording of simple physiological variables. The goal of CXE is to further our understanding of human adaptation to cellular hypoxia, a fundamental mechanism of injury in critical illness, with the aim of improving the care of critically ill patients. © 2007 BioMed Central Ltd.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Medical Physiology
Research Field:Systems Physiology
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Edwards, LM (Dr Lindsay Edwards)
ID Code:64499
Year Published:2007
Web of Science® Times Cited:22
Deposited By:Medicine (Discipline)
Deposited On:2010-08-05
Last Modified:2011-09-30
Downloads:0

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