eCite Digital Repository

Invited review: Mitochondria in heart failure

Citation

Murray, AJ and Edwards, LM and Clarke, K, Invited review: Mitochondria in heart failure, Current Opinion in Clinical Nutrition and Metabolic Care, 10, (6) pp. 704-711. ISSN 1363-1950 (2007) [Refereed Article]

DOI: doi:10.1097/MCO.0b013e3282f0ecbe

Abstract

PURPOSE OF REVIEW: Energetic abnormalities in cardiac and skeletal muscle occur in heart failure and correlate with clinical symptoms and mortality. It is likely that the cellular mechanism leading to energetic failure involves mitochondrial dysfunction. Therefore, it is crucial to elucidate the causes of mitochondrial myopathy, in order to improve cardiac and skeletal muscle function, and hence quality of life, in heart failure patients. RECENT FINDINGS: Recent studies identified several potential stresses that lead to mitochondrial dysfunction in heart failure. Chronically elevated plasma free fatty acid levels in heart failure are associated with decreased metabolic efficiency and cellular insulin resistance. Tissue hypoxia, resulting from low cardiac output and endothelial impairment, can lead to oxidative stress and mitochondrial DNA damage, which in turn causes dysfunction and loss of mitochondrial mass. Therapies aimed at protecting mitochondrial function have shown promise in patients and animal models with heart failure. SUMMARY: Despite current therapies, which provide substantial benefit to patients, heart failure remains a relentlessly progressive disease, and new approaches to treatment are necessary. Novel pharmacological agents are needed that optimize substrate metabolism and maintain mitochondrial integrity, improve oxidative capacity in heart and skeletal muscle, and alleviate many of the clinical symptoms associated with heart failure. © 2007 Lippincott Williams & Wilkins, Inc.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Edwards, LM (Dr Lindsay Edwards)
ID Code:64375
Year Published:2007
Web of Science® Times Cited:48
Deposited By:Medicine (Discipline)
Deposited On:2010-07-21
Last Modified:2012-02-27
Downloads:0

Repository Staff Only: item control page