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The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study
Citation
Stannus, OP and Jones, G and Quinn, SJ and Cicuttini, FM and Dore, D and Ding, C, The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study, Arthritis Research & Therapy, 12, (3) EJ ISSN 1478-6354 (2010) [Refereed Article]
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Copyright Statement
© 2010 Stannus et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI: doi:10.1186/ar3022
Abstract
Introduction: The associations between leptin, interleukin (IL)-6, and hip radiographic osteoarthritis (OA) have not been reported, and their roles in obesity-related hip OA are unclear. The aim of this study was to describe the
associations between leptin, IL-6, and hip radiographic osteoarthritis (ROA) in older adults.
Methods: A cross-sectional sample of 193 randomly selected subjects (mean age, 63 years; range, 52 to 78 years; 48% female subjects) were studied. Hip ROA, including joint-space narrowing (JSN) and osteophytes, was determined by
anteroposterior radiograph. Serum levels of leptin and interleukin (IL)-6 were measured with radioimmunoassay. Fat mass was measured with dual-energy x-ray absorptiometry (DXA). Body mass index (BMI) and waist-to-hip ratio (WHR)
were calculated.
Results: In multivariable analysis, hip JSN was associated with serum levels of leptin in the whole sample (β = 0.046 per μg/L, P = 0.024 for superior; β = 0.068 per μg/L, P = 0.004 for axial compartment) and IL-6 only in females (β = 0.241 per pg/ml, P = 0.002 for superior; β = 0.239 per pg/ml, P = 0.001 for axial compartment). The positive associations between body-composition measures (BMI, WHR, percentage total fat mass, and percentage trunk fat mass) and hip JSN in women became nonsignificant after adjustment for leptin but not for IL-6. No significant associations were found between leptin, IL-6, and the presence or severity of osteophytes.
Conclusions: This study suggests that metabolic and inflammatory mechanisms may play a role in the etiology of hip OA and that the associations between body composition and hip JSN are mediated by leptin, particularly in women.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Clinical sciences |
| Research Field: | Rheumatology and arthritis |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Stannus, OP (Mr Oliver Stannus) |
| UTAS Author: | Jones, G (Professor Graeme Jones) |
| UTAS Author: | Quinn, SJ (Dr Stephen Quinn) |
| UTAS Author: | Dore, D (Associate Professor Dawn Aitken) |
| UTAS Author: | Ding, C (Professor Chang-Hai Ding) |
| ID Code: | 64062 |
| Year Published: | 2010 |
| Web of Science® Times Cited: | 56 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2010-06-22 |
| Last Modified: | 2011-04-29 |
| Downloads: | 529 View Download Statistics |
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