eCite Digital Repository

The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study

Citation

Stannus, OP and Jones, G and Quinn, SJ and Cicuttini, FM and Dore, D and Ding, C, The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study, Arthritis Research & Therapy, 12, (3) EJ ISSN 1478-6354 (2010) [Refereed Article]


Preview
PDF
3Mb
  

Copyright Statement

© 2010 Stannus et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI: doi:10.1186/ar3022

Abstract

Introduction: The associations between leptin, interleukin (IL)-6, and hip radiographic osteoarthritis (OA) have not been reported, and their roles in obesity-related hip OA are unclear. The aim of this study was to describe the associations between leptin, IL-6, and hip radiographic osteoarthritis (ROA) in older adults. Methods: A cross-sectional sample of 193 randomly selected subjects (mean age, 63 years; range, 52 to 78 years; 48% female subjects) were studied. Hip ROA, including joint-space narrowing (JSN) and osteophytes, was determined by anteroposterior radiograph. Serum levels of leptin and interleukin (IL)-6 were measured with radioimmunoassay. Fat mass was measured with dual-energy x-ray absorptiometry (DXA). Body mass index (BMI) and waist-to-hip ratio (WHR) were calculated. Results: In multivariable analysis, hip JSN was associated with serum levels of leptin in the whole sample (β = 0.046 per μg/L, P = 0.024 for superior; β = 0.068 per μg/L, P = 0.004 for axial compartment) and IL-6 only in females (β = 0.241 per pg/ml, P = 0.002 for superior; β = 0.239 per pg/ml, P = 0.001 for axial compartment). The positive associations between body-composition measures (BMI, WHR, percentage total fat mass, and percentage trunk fat mass) and hip JSN in women became nonsignificant after adjustment for leptin but not for IL-6. No significant associations were found between leptin, IL-6, and the presence or severity of osteophytes. Conclusions: This study suggests that metabolic and inflammatory mechanisms may play a role in the etiology of hip OA and that the associations between body composition and hip JSN are mediated by leptin, particularly in women.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Stannus, OP (Mr Oliver Stannus)
Author:Jones, G (Professor Graeme Jones)
Author:Quinn, SJ (Dr Stephen Quinn)
Author:Dore, D (Dr Dawn Aitken)
Author:Ding, C (Professor Chang-Hai Ding)
ID Code:64062
Year Published:2010
Web of Science® Times Cited:36
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-06-22
Last Modified:2011-04-29
Downloads:406 View Download Statistics

Repository Staff Only: item control page