eCite Digital Repository
The Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Cancer
Citation
Murchison, EP and Tovar, C and Hsu, A and Bender, HS and Kheradpour, P and Rebbeck, CA and Obendorf, D and Conlan, C and Bahlo, M and Blizzard, CA and Pyecroft, S and Kreiss, A and Kellis, M and Stark, A and Harkins, TT and Marshall Graves, JA and Woods, GM and Hannon, GJ and Papenfuss, AT, The Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Cancer , Science, 327, (5961) pp. 84-87. ISSN 0036-8075 (2010) [Refereed Article]
 | PDF Restricted - Request a copy 411Kb |
Copyright Statement
Copyright 2009 by the American Association for the Advancement of Science
DOI: doi:10.1126/science.1180616
Abstract
The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD
with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin. On the basis of these results, we have
generated a diagnostic marker for DFTD and identify a suite of genes relevant to DFTD pathology and transmission. We provide a genomic data set for the Tasmanian devil that is applicable to cancer diagnosis, disease evolution, and conservation biology.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Immunology |
| Research Field: | Immunogenetics (incl. genetic immunology) |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Tovar, C (Dr Cesar Tovar Lopez) |
| UTAS Author: | Obendorf, D (Dr David Obendorf) |
| UTAS Author: | Blizzard, CA (Dr Catherine Blizzard) |
| UTAS Author: | Kreiss, A (Dr Alexandre Kreiss) |
| UTAS Author: | Woods, GM (Professor Gregory Woods) |
| ID Code: | 64058 |
| Year Published: | 2010 |
| Web of Science® Times Cited: | 159 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2010-06-22 |
| Last Modified: | 2011-06-14 |
| Downloads: | 0 |
Repository Staff Only: item control page