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Focal demyelination in Alzheimer's disease and transgenic mouse models
Citation
Mitew, S and Kirkcaldie, MTK and Halliday, G and Shepherd, CE and Vickers, JC and Dickson, TC, Focal demyelination in Alzheimer's disease and transgenic mouse models, Acta Neuropathologica, 119, (5) pp. 567-577. ISSN 0001-6322 (2010) [Refereed Article]
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Copyright Statement
The original publication is available at www.springerlink.com
DOI: doi:10.1007/s00401-010-0657-2
Abstract
We have investigated alterations in myelin
associated with Ab plaques, a major pathological hallmark
of Alzheimer’s disease (AD), in human tissue and relevant
transgenic mice models. Using quantitative morphological
techniques, we determined that fibrillar Ab pathology in the
grey matter of the neocortex was associated with focal
demyelination in human presenilin-1 familial, sporadic and
preclinical AD cases, as well as in two mouse transgenic
models of AD, compared with age-matched control tissue.
This demyelination was most pronounced at the core of Ab
plaques. Furthermore, we found a focal loss of oligodendrocytes
in sporadic and preclinical AD cases associated
with Ab plaque cores. In human and transgenic mice alike,
plaque-free neocortical regions showed no significant
demyelination or oligodendrocyte loss compared with controls.
Dystrophic neurites associated with the plaques were
also demyelinated. We suggest that such plaque-associated
focal demyelination of the cortical grey matter might impair
cortical processing, and may also be associated with aberrant
axonal sprouting that underlies dystrophic neurite
formation.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | Dystrophic neurites; Demyelination; Abeta plaques; Degeneration; Alzheimer’s disease |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Neurosciences not elsewhere classified |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Mitew, S (Mr Stanislaw Mitew) |
UTAS Author: | Kirkcaldie, MTK (Dr Matthew Kirkcaldie) |
UTAS Author: | Vickers, JC (Professor James Vickers) |
UTAS Author: | Dickson, TC (Professor Tracey Dickson) |
ID Code: | 64012 |
Year Published: | 2010 |
Web of Science® Times Cited: | 103 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2010-06-16 |
Last Modified: | 2013-07-16 |
Downloads: | 2 View Download Statistics |
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