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Targeting IL-6 in the treatment of inflammatory and autoimmune diseases

Citation

Ding, C and Cicuttini, F and Li, J and Jones, G, Targeting IL-6 in the treatment of inflammatory and autoimmune diseases, Expert Opinion on Investigational Drugs, 18, (10) pp. 1457-1466. (2009) [Substantial Review]

DOI: doi:10.1517/13543780903203789

Abstract

Background: IL-6, a glycoprotein composed of 212 amino acids in human, has a wide range of biological activity, including regulation of immune response, support of hematopoiesis, generation of acute-phase reactions and induction of inflammation and oncogenesis. Several approaches including inhibition of IL-6 production, blockage of IL-6 binding to IL-6 receptor, blockage of IL-6/IL-6R complex binding to gp 130 and blockage of the intracytoplasmic signal through gp 130 can be used to block IL-6 functions. Objective: To summarize pre-clinical development and efficacy and safety of anti-IL-6 therapies in the treatment of inflammatory and autoimmune diseases. Methods: Journal articles found within a PubMed search and data presented in abstract form from international conferences up to May 2009 are described in this review. Results/conclusions: Tocilizumab, which blocks IL-6 binding to IL-6 receptor, used as monotherapy or in combination with methotrexate for RA therapy leads to significant clinical response and amelioration of joint damage, which is superior to methotrexate. Some adverse events such as liver function disorders, hyperlipidemia, neutropenia, diarrhea and infection are observed in clinical trials. IL-6 blockers targeting directly IL-6 rather than the IL-6 receptor and fully human monoclonal antibody targeting the IL-6 receptor are currently under development. Overall, targeting IL-6 has provided a promising approach in the management of some inflammatory and autoimmune diseases. © 2009 Informa UK Ltd. All rights reserved.

Item Details

Item Type:Substantial Review
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Ding, C (Professor Chang-Hai Ding)
Author:Jones, G (Professor Graeme Jones)
ID Code:63920
Year Published:2009
Web of Science® Times Cited:50
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-06-09
Last Modified:2010-06-09
Downloads:0

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