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The two faces of metallothionein in carcinogenesis: photoprotection against UVR-induced cancer and promotion of tumour survival

Citation

McGee, HM and Woods, GM and Bennett, B and Chung, RS, The two faces of metallothionein in carcinogenesis: photoprotection against UVR-induced cancer and promotion of tumour survival, Photochemical & Photobiological Sciences, 9, (4) pp. 586-596. (2010) [Substantial Review]

DOI: doi:10.1039/b9pp00155g

Abstract

Metallothionein is a multi-functional protein that protects the host against toxic heavy metals. Under stressful situations it can protect against oxidative damage, contribute to tissue repair, modulate immune responses and limit inflammatory processes. Recently, metallothionein's role in ultraviolet radiation (UVR)-induced injury has been investigated. These studies have shown that when metallothionein is upregulated following exposure to UVR, it can protect against UVR-induced damage and the subsequent development of skin cancer. We propose that this initial protection is achieved through its anti-oxidant role resulting in reduced oxidative stress, reduced apoptosis, reduced NFκB activation and enhanced repair of DNA damage. However, once UVR-induced neoplasia has occurred, the cancer cells can hijack metallothionein's protective functions, resulting in increased tumour progression and malignancy. These two discordant sets of attributes are context-dependent, and represent the two faces of metallothionein. © The Royal Society of Chemistry and Owner Societies 2010.

Item Details

Item Type:Substantial Review
Research Division:Medical and Health Sciences
Research Group:Oncology and Carcinogenesis
Research Field:Cancer Cell Biology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:McGee, HM (Dr Heather McGee)
Author:Woods, GM (Professor Gregory Woods)
Author:Bennett, B (Dr Bill Bennett)
Author:Chung, RS (Associate Professor Roger Chung)
ID Code:63806
Year Published:2010
Web of Science® Times Cited:21
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-06-01
Last Modified:2010-06-01
Downloads:0

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