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This paper examines the evidence for an MDMA or "ecstasy" dependence syndrome. Animal evidence suggests that MDMA may be a less potent reinforcer than other drugs, but that it does have dependence potential. This suggests that (a) ecstasy dependence might be less likely than dependence upon other drugs; and (b) factors related to the behavioural and psychological aspects of reward and dependence may make a relatively greater contribution for ecstasy than for other drugs, where physically centred (and better understood) features of dependence may be more salient. Human evidence supports this proposition. Some people report problems with their use, but the literature suggests that physical features play a more limited role than psychological ones. Tolerance is apparent, and withdrawal is self-reported, but it is unclear whether these reports distinguish sub-acute effects of ecstasy intoxication from symptoms reflective of neuroadaptive processes underlying a "true" withdrawal syndrome. Studies examining the structure of dependence upon ecstasy suggest it may be different from drugs such as alcohol, methamphetamine and opioids. Consistent with studies of hallucinogens, a two-factor structure has been identified with factors suggestive of "compulsive use" and "escalating use". Regardless of the nature of any dependence syndrome, however, there is evidence to suggest that a minority of ecstasy users become concerned about their use and seek treatment. Further controlled studies are required to investigate this phenomenon.

Item Type:	Refereed Article
Keywords:	Dependence; MDMA; Ecstasy; Amphetamines; Nosology
Research Division:	Medical and Health Sciences
Research Group:	Public Health and Health Services
Research Field:	Mental Health
Objective Division:	Health
Objective Group:	Public Health (excl. Specific Population Health)
Objective Field:	Substance Abuse
Author:	Bruno, RB (Associate Professor Raimondo Bruno)
ID Code:	63790
Year Published:	2010
Web of Science® Times Cited:	51
Deposited By:	Psychology
Deposited On:	2010-05-31
Last Modified:	2011-04-12
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