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Influence of altered blood rheology on ventricular-vascular response to exercise

Citation

Sharman, JE and Brown, J and Holland, DJ and Macdonald, G and Kostner, K and Marwick, TH, Influence of altered blood rheology on ventricular-vascular response to exercise, Hypertension, 54, (5) pp. 1092-1098. ISSN 0194-911X (2009) [Refereed Article]


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Copyright Statement

Copyright 2009 American Heart Association

DOI: doi:10.1161/HYPERTENSIONAHA.109.135525

Abstract

Blood (or plasma) rheology is related to cardiovascular risk. Mechanisms of this association are unclear but may be partially related to impaired left ventricular (LV) function and increased central blood pressure (BP) during light activity. This study aimed to test these hypotheses. Twenty patients (14 men; aged 6112 years) with polycythemia rubra vera (n=16) or hemochromatosis (n=4) were studied at rest and during exercise at ~50% of maximal heart rate before and after venesection (500 mL; volume replaced with saline) to elicit an acute decrease in plasma viscosity at stable BP. Controls (n=20) underwent the same protocol with 25-mL venesection. Central BP and augmentation index were determined by tonometry. Resting LV systolic (peak longitudinal systolic strain rate and strain) and diastolic functions were determined by tissue-Doppler echocardiography. Venesection with blood volume replacement decreased viscosity (1.460.10 to 1.410.11 centipoise), protein, and hemoglobin (P<0.05 for all) and increased strain rate and strain (P<0.001 for both) in patients but not in controls (P>0.10 for all). There was no change in LV diastolic function (P>0.12 for all). Exercise augmentation index in patients was reduced after venesection (2412% to 179%; P=0.001) despite no significant change in other BP variables. Hemodynamics (resting or exercise) were not significantly changed in controls. Exercise central systolic BP correlated with triglycerides (r=0.59; P<0.001). However, neither exercise hemodynamic changes nor LV functional changes correlated with any biochemical changes after venesection (P>0.05). We conclude that an acute change in blood rheology improves ventricular-vascular interaction by enhanced LV systolic function and reduced light-exercise central BP.

Item Details

Item Type:Refereed Article
Keywords:blood pressure, hemodynamics, blood viscosity, heart ventricles, exercise
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Sharman, JE (Professor James Sharman)
Author:Marwick, TH (Professor Tom Marwick)
ID Code:63744
Year Published:2009
Web of Science® Times Cited:12
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-05-26
Last Modified:2014-12-17
Downloads:0

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