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Identification of Quantitative Trait Loci responsible for embryonic lethality in mice assessed by ultrasonography


Laissue, P and Burgio, GR and L'Hote, D and Renault, G and Marchiol-Fournigault, C and Fradelizi, D and Fellous, M and Serres, C and Montagutelli, X and Monget, P and Vaiman, D, Identification of Quantitative Trait Loci responsible for embryonic lethality in mice assessed by ultrasonography, The International Journal of Developmental Biology, 53, (4) pp. 623-629. ISSN 0214-6282 (2009) [Refereed Article]

DOI: doi:10.1387/ijdb.082613pl


Recurrent Spontaneous Abortion (RSA) is a frequent pathology affecting 1 to 5% of couples. In ∼50 % of cases, the aetiology is unknown suggesting a subtle interaction between genetic and environmental factors. Previous attempts to describe genetic factors using the candidate gene approach have been relatively unsuccessful due to the physiological, cellular and genetic complexity of mammalian reproduction. Indeed, fertility can be considered as a quantitative feature resulting from the interaction of genetic, epigenetic and environmental factors. Herein, we identified Quantitative Trait Loci (QTL) associated with diverse embryonic lethality phenotypes and the subsequent embryonic resorption in 39 inter-specific recombinant congenic mice strains, using in vivo ultrasound bio-microscopy. The short chromosomal intervals related to the phenotypes will facilitate the study of a restricted number of candidate genes which are potentially dysregulated in patients affected by RSA. © 2009 UBC Press.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Genome structure and regulation
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Burgio, GR (Dr Gaetan Burgio)
ID Code:63724
Year Published:2009
Web of Science® Times Cited:22
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-05-26
Last Modified:2010-05-26

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