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Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance


Okamoto, H and Hribal, ML and Lin, HV and Bennett, WR and Ward, A and Accili, D, Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance, Journal of Clinical Investigation, 116, (3) pp. 775-782. ISSN 0021-9738 (2006) [Refereed Article]

DOI: doi:10.1172/JCI24967


Diabetes is associated with defective β cell function and altered β cell mass. The mechanisms regulating β cell mass and its adaptation to insulin resistance are unknown. It is unclear whether compensatory β cell hyperplasia is achieved via proliferation of existing β cells or neogenesis from progenitor cells embedded in duct epithelia. We have used transgenic mice expressing a mutant form of the forkhead-O1 transcription factor (FoxO1) in both pancreatic ductal and endocrine β cells to assess the contribution of these 2 compartments to islet expansion. We show that the mutant FoxO1 transgene prevents β cell replication in 2 models of β cell hyperplasia, 1 due to peripheral insulin resistance (Insulin receptor transgenic knockouts) and 1 due to ectopic local expression of IGF2 (Elastase-IGF2 transgenics), without affecting insulin secretion. In contrast, we failed to detect a specific effect of the FoxO1 transgene on the number of periductal β cells. We propose that β cell compensation to insulin resistance is a proliferative response of existing β cells to growth factor signaling and requires FoxO1 nuclear exclusion.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Developmental genetics (incl. sex determination)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Bennett, WR (Dr Bill Bennett)
ID Code:63718
Year Published:2006
Web of Science® Times Cited:92
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-05-26
Last Modified:2010-05-26

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