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Nucleotide polymorphisms of the bovine growth hormone secretagogue receptor 1a (GHSR1a) gene and their association with growth and carcass traits in Japanese Black cattle
Citation
Komatsu, M and Fujimori, Y and Sato, Y and Itoh, T and Satoh, M and Malau-Aduli, AEO and Takahashi, H, Nucleotide polymorphisms of the bovine growth hormone secretagogue receptor 1a (GHSR1a) gene and their association with growth and carcass traits in Japanese Black cattle, 9th World Congress on Genetics Applied to Livestock Production : proceedings, 1-6 August 2010, Leipzig, Germany EJ ISBN 978-3-00-031608-1 (2010) [Refereed Conference Paper]
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Copyright © 2010 wcgalp2010
Official URL: http://www.wcgalp2010.org/
Abstract
Ghrelin growth hormone secretagogue receptor 1a (GHSR1a) is involved in many
important functions, including growth hormone secretion and food intake (Howard et al.
1996). To the best of our knowledge, there have been no reports to date on nucleotide
polymorphisms from the 5’-flanking region to the 3’-UTR nor on the transcriptional
analysis of the 5’-UTR of the GHSR1a gene in cattle. In our previous study (Malau-Aduli
et al. (2005)), the GHSR1a gene was reported as a potential candidate gene when we
detected growth trait QTLs in Japanese Black cattle using microsatellite DNA markers and
half-sib regression analysis. Here we describe (1) all possible nucleotide polymorphisms
from the 5’-flanking region to the 3’-UTR of the GHSR1a gene, (2) the transcript sequences
of the 5’-UTR of the gene, which allows one to determine whether the microsatellite locus
has been transcribed, and (3) an association between nucleotide polymorphisms of the gene
and growth and carcass traits in Japanese Black cattle (Komatsu et al. (2010)). Finally, we
propose a hypothesis that the association is due to differences in RNA secondary structure
of the GHSR 1b mRNA.
Item Details
| Item Type: | Refereed Conference Paper |
|---|---|
| Research Division: | Biological Sciences |
| Research Group: | Genetics |
| Research Field: | Genomics |
| Objective Division: | Animal Production and Animal Primary Products |
| Objective Group: | Livestock Raising |
| Objective Field: | Beef Cattle |
| Author: | Malau-Aduli, AEO (Associate Professor Aduli Malau-Aduli) |
| ID Code: | 63678 |
| Year Published: | 2010 |
| Deposited By: | Agricultural Science |
| Deposited On: | 2010-05-21 |
| Last Modified: | 2012-02-27 |
| Downloads: | 0 |
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