eCite Digital Repository

Nucleotide polymorphisms of the bovine growth hormone secretagogue receptor 1a (GHSR1a) gene and their association with growth and carcass traits in Japanese Black cattle

Citation

Komatsu, M and Fujimori, Y and Sato, Y and Itoh, T and Satoh, M and Malau-Aduli, AEO and Takahashi, H, Nucleotide polymorphisms of the bovine growth hormone secretagogue receptor 1a (GHSR1a) gene and their association with growth and carcass traits in Japanese Black cattle, 9th World Congress on Genetics Applied to Livestock Production : proceedings, 1-6 August 2010, Leipzig, Germany EJ ISBN 978-3-00-031608-1 (2010) [Refereed Conference Paper]

PDF
Not available
51Kb
  

Copyright Statement

Copyright 2010 wcgalp2010

Official URL: http://www.wcgalp2010.org/

Abstract

Ghrelin growth hormone secretagogue receptor 1a (GHSR1a) is involved in many important functions, including growth hormone secretion and food intake (Howard et al. 1996). To the best of our knowledge, there have been no reports to date on nucleotide polymorphisms from the 5-flanking region to the 3-UTR nor on the transcriptional analysis of the 5-UTR of the GHSR1a gene in cattle. In our previous study (Malau-Aduli et al. (2005)), the GHSR1a gene was reported as a potential candidate gene when we detected growth trait QTLs in Japanese Black cattle using microsatellite DNA markers and half-sib regression analysis. Here we describe (1) all possible nucleotide polymorphisms from the 5-flanking region to the 3-UTR of the GHSR1a gene, (2) the transcript sequences of the 5-UTR of the gene, which allows one to determine whether the microsatellite locus has been transcribed, and (3) an association between nucleotide polymorphisms of the gene and growth and carcass traits in Japanese Black cattle (Komatsu et al. (2010)). Finally, we propose a hypothesis that the association is due to differences in RNA secondary structure of the GHSR 1b mRNA.

Item Details

Item Type:Refereed Conference Paper
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Genomics
Objective Division:Animal Production and Animal Primary Products
Objective Group:Livestock Raising
Objective Field:Beef Cattle
Author:Malau-Aduli, AEO (Associate Professor Aduli Malau-Aduli)
ID Code:63678
Year Published:2010
Deposited By:Agricultural Science
Deposited On:2010-05-21
Last Modified:2012-02-27
Downloads:0

Repository Staff Only: item control page