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SPARC is expressed by macroglia and microglia in the developing and mature nervous system


Vincent, AJ and Lau, P and Roskams, AJ, SPARC is expressed by macroglia and microglia in the developing and mature nervous system, Developmental Dynamics, 237, (5) pp. 1449-1462. ISSN 1058-8388 (2008) [Refereed Article]

DOI: doi:10.1002/dvdy.21495


SPARC (secreted protein, acidic and rich in cysteine) is a matricellular protein that is highly expressed during development, tissue remodeling, and repair. SPARC produced by olfactory ensheathing cells (OECs) can promote axon sprouting in vitro and in vivo. Here, we show that in the developing nervous system of the mouse, SPARC is expressed by radial glia, blood vessels, and other pial-derived structures during embryogenesis and postnatal development. The rostral migratory stream contains SPARC that becomes progressively restricted to the SVZ in adulthood. In the adult CNS, SPARC is enriched in specialized radial glial derivatives (Müller and Bergmann glia), microglia, and brainstem astrocytes. The peripheral glia, Schwann cells, and OECs express SPARC throughout development and in maturity, although it appears to be down-regulated with maturation. These data suggest that SPARC may be expressed by glia in a spatiotemporal manner consistent with a role in cell migration, neurogenesis, synaptic plasticity, and angiogenesis.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the environmental sciences
UTAS Author:Vincent, AJ (Dr Adele Vincent)
ID Code:63661
Year Published:2008
Web of Science® Times Cited:49
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-05-20
Last Modified:2010-06-18

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