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Metabolic controls in precancerous liver: V. Loss of control of cholesterol synthesis during feeding of the hepatocarcinogen 3-methyl-4-dimethylaminoazobenzene

Citation

Horton, BJ and Horton, JD and Pitot, HC and Sabine, JR, Metabolic controls in precancerous liver: V. Loss of control of cholesterol synthesis during feeding of the hepatocarcinogen 3-methyl-4-dimethylaminoazobenzene, European Journal of Cancer, 9 pp. 573-576. ISSN 0959-8049 (1973) [Refereed Article]

DOI: doi:10.1016/0014-2964(73)90147-3

Abstract

We have examined dietary control of cholesterol synthesis in rat liver during the feeding of 3′-methyl-4-dimethyl-aminoazobenzene (3′ MeDAB), using an assay which permits repeated tests on the same animal. Synthesis was measured as plasma levels of 7-dehydrocholesterol following a single dose of AY-9944 (trans1,4-bis (2-chlorobenzylaminomethyl) cyclohexane dihydrochloride), a drug which inhibits the conversion of 7-dehydrocholesterol to cholesterol. During 3′ MeDAB feeding there was a significant loss of inhibition of sterol synthesis in response to cholesterol feeding, but control rapidly returned to normal as soon as the carcinogen treatment was discontinued. The loss of control observed here was similar to that previously reported for 3 other hepatocarcinogens. © 1973.

Item Details

Item Type:Refereed Article
Research Division:Agricultural and Veterinary Sciences
Research Group:Animal Production
Research Field:Animal Protection (Pests and Pathogens)
Objective Division:Animal Production and Animal Primary Products
Objective Group:Livestock Raising
Objective Field:Sheep - Wool
Author:Horton, BJ (Dr Brian Horton)
ID Code:63475
Year Published:1973
Web of Science® Times Cited:7
Deposited By:Agricultural Science
Deposited On:2010-05-07
Last Modified:2011-06-15
Downloads:0

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