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Spontaneous tumours in C3H-Avy and C3H-AvyfB mice: High incidence in the United States, low incidence in Australia

Citation

Sabine, JR and Horton, BJ and Wicks, MB, Spontaneous tumours in C3H-Avy and C3H-AvyfB mice: High incidence in the United States, low incidence in Australia, National Cancer Institute. Journal, 50 pp. 1237-1242. ISSN 0027-8874 (1973) [Refereed Article]

DOI: doi:10.1093/jnci/50.5.1237

Abstract

C3H-Avyy and C3H-Avy, fB mice, with a virtual 100% incidence of liver and mammary tumors in the United States, had an almost 0% incidence of these tumors when these mice were bred and reared in Australia, particularly after the first generation. C3H-Avymice, when reared in Australia but provided with U.S. feed and bedding (cedar shavings), also had essentially a 100% incidence of mammary tumors. Although our results did not rule out other possibilities, the implication of cedar as a "carcinogenic” agent was quite clear-cut. These observations, although not yet made on large numbers of mice, provide new parameters for the study and understanding of the development of spontaneous mammary and liver cancer in mice.â€"J Natl Cancer Inst 50: 1237-1242, 1973. © 1973 OUP Publishing Ltd.

Item Details

Item Type:Refereed Article
Research Division:Agricultural and Veterinary Sciences
Research Group:Animal Production
Research Field:Animal Protection (Pests and Pathogens)
Objective Division:Animal Production and Animal Primary Products
Objective Group:Livestock Raising
Objective Field:Sheep - Wool
Author:Horton, BJ (Dr Brian Horton)
ID Code:63470
Year Published:1973
Web of Science® Times Cited:42
Deposited By:Agricultural Science
Deposited On:2010-05-07
Last Modified:2010-05-07
Downloads:0

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