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Spontaneous tumours in C3H-Avy and C3H-AvyfB mice: High incidence in the United States, low incidence in Australia
Citation
Sabine, JR and Horton, BJ and Wicks, MB, Spontaneous tumours in C3H-Avy and C3H-AvyfB mice: High incidence in the United States, low incidence in Australia, National Cancer Institute. Journal, 50 pp. 1237-1242. ISSN 0027-8874 (1973) [Refereed Article]
DOI: doi:10.1093/jnci/50.5.1237
Abstract
C3H-Avyy and C3H-Avy, fB mice, with a virtual 100% incidence of liver and mammary tumors in the United States, had an almost 0% incidence of these tumors when these mice were bred and reared in Australia, particularly after the first generation. C3H-Avymice, when reared in Australia but provided with U.S. feed and bedding (cedar shavings), also had essentially a 100% incidence of mammary tumors. Although our results did not rule out other possibilities, the implication of cedar as a "carcinogenic” agent was quite clear-cut. These observations, although not yet made on large numbers of mice, provide new parameters for the study and understanding of the development of spontaneous mammary and liver cancer in mice.â€"J Natl Cancer Inst 50: 1237-1242, 1973. © 1973 OUP Publishing Ltd.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Agricultural and Veterinary Sciences |
| Research Group: | Animal Production |
| Research Field: | Animal Protection (Pests and Pathogens) |
| Objective Division: | Animal Production and Animal Primary Products |
| Objective Group: | Livestock Raising |
| Objective Field: | Sheep - Wool |
| Author: | Horton, BJ (Dr Brian Horton) |
| ID Code: | 63470 |
| Year Published: | 1973 |
| Web of Science® Times Cited: | 42 |
| Deposited By: | Agricultural Science |
| Deposited On: | 2010-05-07 |
| Last Modified: | 2010-05-07 |
| Downloads: | 0 |
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