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Control of cholesterol synthesis in hepatomas: Absence of diurnal rhythm in Morris hepatomas 7794A and 9618A

Citation

Sabine, JR and Horton, BJ and Hickman, PE, Control of cholesterol synthesis in hepatomas: Absence of diurnal rhythm in Morris hepatomas 7794A and 9618A, European Journal of Cancer, 8 pp. 29-32. ISSN 0959-8049 (1972) [Refereed Article]

DOI: doi:10.1016/0014-2964(72)90080-1

Abstract

We have examined the Morris hepatomas 7794A and 9618A for the presence of a diurnal variation in cholesterol synthesis such as is observed in the livers of normal rats. Whereas the livers of the tumour-bearing animals showed a 3-5 fold increase in rate of cholesterol synthesis from acetate between midday and midnight, no such increase occurred in the hepatomas. Furthermore, adrenalectomy resulted in a 3-fold increase in cholesterol synthesis (as measured at midday) in the host liver, but not in hepatoma 7794A. Work by others has indicated that diurnal variations in cholesterol synthesis in normal liver are due to variations in the amount rather than in the specific activity of the ratecontrolling enzyme of the cholesterogenic pathway, namely β-hydroxy-β-methylglutaryl co-enzyme A reductase. Our work has now demonstrated that at least two of the "minimal-deviation" hepatomas exhibit a defect in control over the synthesis and/or degradation of this enzyme, i.e. in addition to the defective "feedback" control of its activity that has been shown in many previous reports. © 1972.

Item Details

Item Type:Refereed Article
Research Division:Agricultural and Veterinary Sciences
Research Group:Animal Production
Research Field:Animal Protection (Pests and Pathogens)
Objective Division:Animal Production and Animal Primary Products
Objective Group:Livestock Raising
Objective Field:Sheep - Wool
Author:Horton, BJ (Dr Brian Horton)
ID Code:63456
Year Published:1972
Web of Science® Times Cited:17
Deposited By:Agricultural Science
Deposited On:2010-05-07
Last Modified:2010-05-07
Downloads:0

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